Allergic diseases in the elderly: biological characteristics and main immunological and non-immunological mechanisms
| العنوان: | Allergic diseases in the elderly: biological characteristics and main immunological and non-immunological mechanisms |
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| المؤلفون: | Giorgio Walter Canonica, Stefano Del Giacco, Nicola Scichilone, Livio Simioni, Maria Teresa Ventura, Erminia Ridolo, Vincenzo Patella, Roberto Paganelli, Matteo Bonini, Paola Lucia Minciullo, Giovanni Passalacqua, Sebastiano Gangemi, Carlo Lombardi |
| المساهمون: | Ventura M.T., Scichilone N., Paganelli R., Minciullo P.L., Patella V., Bonini M., Passalacqua G., Lombardi C., Simioni L., Ridolo E., Del Giacco S.R., Gangemi S., Canonica G.W. |
| المصدر: | Clinical and molecular allergy (Online) 15 (2017). doi:10.1186/s12948-017-0059-2 info:cnr-pdr/source/autori:Ventura M.T.; Scichilone N.; Paganelli R.; Minciullo P.L.; Patella V.; Bonini M.; Passalacqua G.; Lombardi C.; Simioni L.; Ridolo E.; Giacco S.R.; Gangemi S.; Canonica G.W./titolo:Allergic diseases in the elderly: Biological characteristics and main immunological and non-immunological mechanisms/doi:10.1186%2Fs12948-017-0059-2/rivista:Clinical and molecular allergy (Online)/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:15 Clinical and Molecular Allergy : CMA |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Aging, Allergy, Urticaria, medicine.medical_treatment, Immunology, Environmental pollution, Review, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 03 medical and health sciences, Elderly, Immune system, Anaphylaxi, Food allergy, medicine, Immunology and Allergy, Anaphylaxis, Molecular Biology, Asthma, business.industry, Conjunctiviti, Immunotherapy, Conjunctivitis, medicine.disease, Drug reaction, 030104 developmental biology, age, Life expectancy, business |
| الوصف: | Life expectancy and the number of elderly people are progressively increasing around the world. Together with other pathologies, allergic diseases also show an increasing incidence in geriatric age. This is partly due to the growing emphasis on a more accurate and careful diagnosis of the molecular mechanisms that do not allow to ignore the real pathogenesis of many symptoms until now unknown, and partly to the fact that the allergic people from 20 years ago represent the elderly population now. Moreover, environmental pollution predisposes to the onset of allergic asthma and dermatitis which are the result of internal pathologies more than the expression of allergic manifestations. At the same time the food contamination permits the onset of allergic diseases related to food allergy. In this review we provide the state of the art on the physiological changes in the elderly responsible for allergic diseases, their biological characteristics and the major immunological and extra immunological mechanisms. Much emphasis is given to the management of several diseases in the elderly, including anaphylactic reactions. Moreover, some new features are discussed, such as management of asthma with the support of physical activity and the use of the AIT as prevention of respiratory diseases and for the purpose of a real and long lasting benefit. The mechanisms of adverse reactions to drugs are also discussed, due to their frequency in this age, especially in polytherapy regimens. Study of the modifications of the immune system is also of great importance, as regards to the distribution of the lymphocytes and also the presence of a chronic inflammatory disease related to the production of cytokines, especially in prevision of all the possible therapies to be adopted to allow an active and healthy aging. |
| تدمد: | 1476-7961 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a298ea509453b11c1912f5f7e6fee3Test https://doi.org/10.1186/s12948-017-0059-2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f0a298ea509453b11c1912f5f7e6fee3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14767961 |
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