Degradation of neutrophil extracellular traps is decreased in patients with antiphospholipid syndrome
| العنوان: | Degradation of neutrophil extracellular traps is decreased in patients with antiphospholipid syndrome |
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| المؤلفون: | Jonatan Leffler, Ljudmila Stojanovich, Yehuda Shoenfeld, Gordana Bogdanovic, Roger Hesselstrand, Blom, Anna M. |
| المصدر: | Lund University University of Western Australia |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Aged, 80 and over, Male, alpha-Defensins, Chi-Square Distribution, Scleroderma, Systemic, Neutrophils, Middle Aged, Antiphospholipid Syndrome, Chromatin, Young Adult, Case-Control Studies, Immunoglobulin G, Humans, Female, Biomarkers, Aged, Autoantibodies |
| الوصف: | A decreased ability to degrade neutrophil extracellular traps (NETs) is seen in a subgroup of patients with systemic lupus erythematosus (SLE) and correlates with the presence of autoantibodies. Antiphospholipid syndrome (APS) can develop secondary to SLE or as a primary disease. In the current study we investigated the ability of sera from patients with APS to degrade NETs. The presence of antibodies against NETs and neutrophil remnants were also determined in the same patients.In the study, 106 patients with APS (73 primary and 33 secondary), 76 patients with systemic sclerosis (SSc) and 77 healthy donors as control samples were included. NETs generated from neutrophils isolated from healthy volunteers were incubated with patient sera, followed by measurement of degraded NETs or deposited IgG.Sera of APS patients had a decreased ability to degrade NETs compared to healthy controls, with no difference between primary and secondary APS. Sera from SSc patients did not differ significantly from healthy controls in the ability to degrade NETs. A decreased degradation of NETs correlated weakly to increased levels of antibodies against NETs/neutrophil remnants in patients with primary APS, but stronger in patients with secondary APS.The ability to degrade NETs is decreased in a subgroup of patients with APS and is associated with antibodies against NETs and specific clinical manifestations in those patients. |
| تدمد: | 0392-856X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::13884461f0b436d79ed032be83df720fTest https://pubmed.ncbi.nlm.nih.gov/24295292Test |
| رقم الانضمام: | edsair.pmid.dedup....13884461f0b436d79ed032be83df720f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0392856X |
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