Expression of cyclooxygenase-1 (COX-1) in labial salivary glands of Sjögren's syndrome
| العنوان: | Expression of cyclooxygenase-1 (COX-1) in labial salivary glands of Sjögren's syndrome |
|---|---|
| المؤلفون: | Yasunori Tsubouchi, Wakako Fukui, Satoshi Yamasaki, Masataka Kohno, Masahiro Tominaga, Hideki Nakamura, K Eguchi, A. Kawakami, Hajime Sano, Seiyo Honda, K Migita, Takaaki Fukuda, Yojiro Kawabe |
| المصدر: | Clinical and Experimental Immunology. 122:459-463 |
| بيانات النشر: | Oxford University Press (OUP), 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Adult, Lipopolysaccharides, medicine.medical_specialty, Systemic disease, Pathology, CD3 Complex, Molecular Sequence Data, Immunology, Antigens, Differentiation, Myelomonocytic, Inflammation, Biology, Monocytes, Salivary Glands, Rheumatic Disease, Antigens, CD, Internal medicine, Biopsy, medicine, Humans, Immunology and Allergy, Amino Acid Sequence, Aged, Autoimmune disease, medicine.diagnostic_test, Salivary gland, CD68, Membrane Proteins, Middle Aged, Antigens, CD20, medicine.disease, Isoenzymes, Sjogren's Syndrome, Endocrinology, medicine.anatomical_structure, Cyclooxygenase 2, Prostaglandin-Endoperoxide Synthases, Cyclooxygenase 1, Immunohistochemistry, Mitogens, medicine.symptom, Immunostaining |
| الوصف: | SUMMARY COX plays an important role in inflammatory diseases such as rheumatoid arthritis. To determine the role of COX in Sjögren's syndrome (SS), we examined COX expression in the salivary glands of SS patients. We examined 15 patients with SS and two normal subjects. Labial salivary gland tissue samples were analysed immunohistochemically using anti-COX-1 and COX-2 antibodies. All biopsy samples from 15 patients with SS were stained for COX-1. In contrast, COX-1 immunostaining was not detected in normal salivary gland tissues. Co-expression of COX-1 and CD68 was confirmed by mirror section technique and double antibody immunostaining. This finding indicated that COX-1-expressing cells in SS salivary glands were infiltrating macrophages. In contrast to COX-1 staining, only a little COX-2 immunostaining was observed in salivary gland tissues from SS patients. These data suggest that COX-1 expression on infiltrating macrophages may contribute to the inflammatory process of salivary glands in SS. |
| تدمد: | 1365-2249 0009-9104 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::637b9d04dd866f2c140d90eac53bc096Test https://doi.org/10.1046/j.1365-2249.2000.01302.xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....637b9d04dd866f2c140d90eac53bc096 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652249 00099104 |
|---|