Moderate exercise improves leucocyte function and decreases inflammation in diabetes
| العنوان: | Moderate exercise improves leucocyte function and decreases inflammation in diabetes |
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| المؤلفون: | Rui Curi, M. F. Belotto, Elaine Hatanaka, Hosana G. Rodrigues, Tania Cristina Pithon-Curi, Juliana Magdalon, Marco Aurélio Ramirez Vinolo |
| المصدر: | Clinical and Experimental Immunology. 162:237-243 |
| بيانات النشر: | Oxford University Press (OUP), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Translational Studies, Neutrophils, Immunology, Apoptosis, Physical exercise, Inflammation, Fatty Acids, Nonesterified, Diabetes Mellitus, Experimental, Proinflammatory cytokine, Necrosis, Insulin resistance, Physical Conditioning, Animal, Internal medicine, Diabetes mellitus, Leukocytes, medicine, Animals, Immunology and Allergy, Rats, Wistar, Creatine Kinase, Peritoneal Cavity, L-Lactate Dehydrogenase, biology, Tumor Necrosis Factor-alpha, business.industry, Interleukins, C-reactive protein, medicine.disease, Rats, C-Reactive Protein, Diabetes Mellitus, Type 1, Endocrinology, Macrophages, Peritoneal, biology.protein, Cytokines, Tetradecanoylphorbol Acetate, Creatine kinase, Tumor necrosis factor alpha, medicine.symptom, Reactive Oxygen Species, business, Chemokines, CXC |
| الوصف: | Summary The genesis and progression of diabetes occur due in part to an uncontrolled inflammation profile with insulin resistance, increased serum levels of free fatty acids (FFA), proinflammatory cytokines and leucocyte dysfunction. In this study, an investigation was made of the effect of a 3-week moderate exercise regimen on a treadmill (60% of VO2max, 30 min/day, 6 days a week) on inflammatory markers and leucocyte functions in diabetic rats. The exercise decreased serum levels of tumour necrosis factor (TNF)-α (6%), cytokine-induced neutrophil chemotactic factor 2 alpha/beta (CINC-2α/β) (9%), interleukin (IL)-1β (34%), IL-6 (86%), C-reactive protein (CRP) (41%) and FFA (40%) in diabetic rats when compared with sedentary diabetic animals. Exercise also attenuated the increased responsiveness of leucocytes from diabetics when compared to controls, diminishing the reactive oxygen species (ROS) release by neutrophils (21%) and macrophages (28%). Exercise did not change neutrophil migration and the proportion of neutrophils and macrophages in necrosis (loss of plasma membrane integrity) and apoptosis (DNA fragmentation). Serum activities of creatine kinase (CK) and lactate dehydrogenase (LDH) were not modified in the conditions studied. Therefore, physical training did not alter the integrity of muscle cells. We conclude that moderate physical exercise has marked anti-inflammatory effects on diabetic rats. This may be an efficient strategy to protect diabetics against microorganism infection, insulin resistance and vascular complications. |
| تدمد: | 1365-2249 0009-9104 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e4e61932b61ef1b43f95e4b2514333Test https://doi.org/10.1111/j.1365-2249.2010.04240.xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d3e4e61932b61ef1b43f95e4b2514333 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652249 00099104 |
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