دورية أكاديمية
أعرض في EDS

Glucocorticoid-Induced TNFR-Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic Modulation

التفاصيل البيبلوغرافية
العنوان: Glucocorticoid-Induced TNFR-Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic Modulation
المؤلفون: Theresa Placke, Hans-Georg Kopp, Helmut Rainer Salih
المصدر: Clinical and Developmental Immunology, Vol 2010 (2010)
بيانات النشر: Hindawi Limited, 2010.
سنة النشر: 2010
المجموعة: LCC:Immunologic diseases. Allergy
مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607
الوصف: The ability of the tumor necrosis factor receptor (TNFR) family member GITR to modulate immune responses has been the subject of multiple studies. Initially thought to be critically involved in governing functions of regulatory T cells, GITR and its ligand GITRL have meanwhile been found to modulate the reactivity of various different cell types and to influence a broad variety of immunological conditions including the immune response against tumors. Not only GITR, but also GITRL is capable of transducing signals, and the consequences of GITR-GITRL interaction may vary among different effector cell types, differ upon signal transduction via the receptor, the ligand, or both, depend on the level of an ongoing immune response, and even differ among mice and men. In this paper, we address available data on GITR and its ligand in immune responses and discuss the role and potential therapeutic modulation of this molecule system in antitumor immunity.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1740-2522
1740-2530
العلاقة: https://doaj.org/toc/1740-2522Test; https://doaj.org/toc/1740-2530Test
DOI: 10.1155/2010/239083
الوصول الحر: https://doaj.org/article/381442bc9b6a43ea8976eebe2b9f3ff0Test
رقم الانضمام: edsdoj.381442bc9b6a43ea8976eebe2b9f3ff0
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17402522
17402530
DOI:10.1155/2010/239083