Megalocornea, anterior megalophthalmos, keratoglobus and associated anterior segment disorders: A review
| العنوان: | Megalocornea, anterior megalophthalmos, keratoglobus and associated anterior segment disorders: A review |
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| المؤلفون: | Andrea L Vincent, Charles N J McGhee, Jie Zhang, Aaron Pin Chien Ong |
| المصدر: | Clinical & Experimental Ophthalmology. 49:477-497 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Keratoconus, medicine.medical_specialty, genetic structures, Anterior megalophthalmos, 030105 genetics & heredity, Cornea, 03 medical and health sciences, Elevated intraocular pressure, Megalocornea, 0302 clinical medicine, Corneal thinning, Ophthalmology, Ciliary ring, medicine, Humans, Eye Abnormalities, business.industry, Hydrophthalmos, Eye Diseases, Hereditary, Genetic Diseases, X-Linked, medicine.disease, eye diseases, Buphthalmos, 030221 ophthalmology & optometry, sense organs, business, Keratoglobus |
| الوصف: | Megalocornea and anterior megalophthalmos (megalocornea spectrum) disorders are typically defined by corneal diameter > 12.5 mm in the absence of elevated intraocular pressure. Clinical features overlap with keratoglobus but are distinct from buphthalmos and severe (globus) keratoconus. Megalocornea spectrum disorders and keratoglobus are primarily congenital disorders, often with syndromic associations; both can present with large and thin corneas, creating difficulty in diagnosis, however, only keratoglobus is typically progressive. Molecular genetics provide significant insight into underlying aetiologies. Nonetheless, careful clinical assessment remains intrinsic to diagnosis. Surgical management can be challenging due to the enlarged ciliary ring and weakened zonules in megalocornea spectrum disorders and the extreme corneal thinning of keratoglobus. In this review, the established literature on measurement of corneal diameter, diagnosis of megalocornea, anterior megalophthalmos and keratoglobus, differentiation from severe keratoconus, recent molecular genetics research and key surgical modalities in the management of these rare disorders are outlined and discussed. |
| تدمد: | 1442-9071 1442-6404 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdfea6313505376d9dd57441c1ff8b1aTest https://doi.org/10.1111/ceo.13958Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....cdfea6313505376d9dd57441c1ff8b1a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14429071 14426404 |
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