التفاصيل البيبلوغرافية
| العنوان: |
CARD9 balances Aspergillus fumigatus‐induced anti‐fungal immunity and allergic inflammation. |
| المؤلفون: |
Xu, Xia, Li, Fan, Huang, Ronghua, Wu, Siyuan, Huang, Zhiwen, Duan, Jielin |
| المصدر: |
Clinical & Experimental Allergy; Jun2023, Vol. 53 Issue 6, p659-663, 5p, 2 Graphs |
| مصطلحات موضوعية: |
IMMUNITY, PULMONARY eosinophilia, ASPERGILLUS, IMMUNOGLOBULIN E, ALVEOLAR macrophages, T helper cells, PULMONARY aspergillosis, ANTIALLERGIC agents |
| مستخلص: |
Keywords: Allergic inflammation; Alveolar macrophages; Aspergillus fumigatus; CARD9 EN Allergic inflammation Alveolar macrophages Aspergillus fumigatus CARD9 659 663 5 06/09/23 20230601 NES 230601 Key message CARD9 enhances pro-inflammatory immune response, but inhibits pulmonary type 2 immunity after I A. fumigatus i exposure. Moreover, we sorted out alveolar macrophages from WT and CARD9 deficient mice infected with/without I A. fumigatus i , and further confirmed that RelB activation only occurred in CARD9 deficient alveolar macrophages. Simultaneously, we found that the expression of CD80, CD86 and MHC-II were comparable between WT and CARD9 deficient mice with/without I A. fumigatus i exposure, hinting that CARD9 did not affect the antigen presentation capacity of alveolar macrophages. CARD9 balances Aspergillus fumigatus-induced anti-fungal immunity and allergic inflammation. [Extracted from the article] |
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| قاعدة البيانات: |
Complementary Index |
