Serum miR-338-3p and miR-199b-5p are associated with the absolute neutrophil count in patients with resectable pancreatic cancer
| العنوان: | Serum miR-338-3p and miR-199b-5p are associated with the absolute neutrophil count in patients with resectable pancreatic cancer |
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| المؤلفون: | Dana A M Mustafa, Fleur van der Sijde, Eveline E. Vietsch, Yunlei Li, Casper H.J. van Eijck |
| المساهمون: | Surgery, Pathology |
| المصدر: | Clinica Chimica Acta, 505, 183-189. Elsevier |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Neutrophils, Lymphocyte, Clinical Biochemistry, Inflammation, Systemic inflammation, Polymerase Chain Reaction, Biochemistry, Cohort Studies, Leukocyte Count, 03 medical and health sciences, 0302 clinical medicine, Immune system, SDG 3 - Good Health and Well-being, Predictive Value of Tests, Internal medicine, medicine, Humans, Peripheral blood cell, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Biochemistry (medical), Reproducibility of Results, General Medicine, Middle Aged, Survival Analysis, Blood Cell Count, Gene Expression Regulation, Neoplastic, Pancreatic Neoplasms, MicroRNAs, Circulating MicroRNA, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cohort, Absolute neutrophil count, Female, medicine.symptom, business |
| الوصف: | Background: Several peripheral blood cell counts and immune ratios, such as the systemic immune-inflammation index (SII = platelet x neutrophil count/lymphocyte count) have prognostic value in patients with resectable pancreatic cancer (PDAC). Circulating microRNAs (miRNAs) are involved in various aspects of cancer and inflammation. We aimed to identify measurable circulating miRNAs in PDAC patients correlating with systemic inflammation parameters. Methods: A total of 42 PDAC patients was included in this study: twelve in the discovery (n = 6 SII low; n = 6 SII high) and 30 patients in the validation cohort (n = 19 SII low, n = 11 SII high). MiRNAs isolated from preoperative serum samples were measured with a 352 miRNA panel in the discovery cohort and individual miRNA primers in the validation cohort, using RT-qPCR (ID3EAL assays, MiRXES). Results: Only in the discovery cohort miR-328-3p, miR-338-3p, miR-1258 and miR-199b-5p were upregulated in high compared to low SII patients (fold difference ≥ 2, P |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1873-3492 0009-8981 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019b4f5a01fac041bdbf42114e44fd67Test https://pure.eur.nl/en/publications/698041a3-1de1-4d54-baa9-4093f4c2e4dcTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....019b4f5a01fac041bdbf42114e44fd67 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18733492 00098981 |
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