Associations Between Alcohol Intake and Genetic Predisposition With Atrial Fibrillation Risk in a National Biobank

التفاصيل البيبلوغرافية
العنوان: Associations Between Alcohol Intake and Genetic Predisposition With Atrial Fibrillation Risk in a National Biobank
المؤلفون: Jennifer L. Halford, Seung Hoan Choi, Valerie N. Morrill, Lu-Chen Weng, Shaan Khurshid, Steven A. Lubitz, Patrick T. Ellinor, Emelia J. Benjamin, Sean J. Jurgens, Ludovic Trinquart
المصدر: Circ Genom Precis Med
سنة النشر: 2020
مصطلحات موضوعية: Male, medicine.medical_specialty, Alcohol Drinking, 030204 cardiovascular system & hematology, Article, Inherited Predisposition, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Primary prevention, Internal medicine, Atrial Fibrillation, Genetic predisposition, Medicine, Humans, Genetic Predisposition to Disease, 030212 general & internal medicine, Risk factor, Gene–environment interaction, Genetic Association Studies, Biological Specimen Banks, business.industry, Incidence, Atrial fibrillation, General Medicine, Middle Aged, medicine.disease, Biobank, Alcohol intake, Female, business
الوصف: Background: Excess alcohol intake and inherited predisposition may increase risk of atrial fibrillation (AF). We assessed the association between alcohol intake, polygenic predisposition to AF, and incident AF in the UK Biobank, a prospective cohort study. Methods: In 376 776 UK Biobank participants enrolled between 2006 and 2010, we tested alcohol consumption (stratified by the Centers of Disease Control and Prevention acceptable range of ≤98 g/wk for women or ≤196 g/wk for men; and as a continuous variable) and an AF polygenic risk score for association with incident AF. Results: Among participants (47.5% male, mean age 56.9 years), 6293 developed AF during a median of 6.9 years of follow-up. Alcohol consumption was associated with AF (hazard ratio, 1.10 [95% CI, 1.05–1.16] for intake above an acceptable range; hazard ratio, 1.04 per 100 g/wk [95% CI, 1.02–1.06]). An AF polygenic risk score was associated with AF (hazard ratio, 1.38 per SD [95% CI, 1.35–1.41]). In models including both alcohol and the AF polygenic risk score, each remained associated with AF. The 5-year cumulative risk of AF for individuals with alcohol intake above an acceptable range and in the highest decile of polygenic risk was 2.33% (95% CI, 2.07–2.59), compared with 0.69% (95% CI, 0.58–0.80) for those with alcohol intake within an acceptable range and in the lowest decile of polygenic risk. Conclusions: Alcohol consumption is associated with increased risk of AF across a range of polygenic predisposition to AF and adds to inherited and clinical predisposition to increase AF susceptibility. Preventive efforts focused on minimizing alcohol intake may be broadly applicable.
تدمد: 2574-8300
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48392983c470abb5068f5d1e8f10a718Test
https://pubmed.ncbi.nlm.nih.gov/33156697Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....48392983c470abb5068f5d1e8f10a718
قاعدة البيانات: OpenAIRE