Abstract 101: The Continuous Administration of Sevoflurane Protects the Heart Against Ischemic Injury via Distinct Mitochondrial Mechanisms
| العنوان: | Abstract 101: The Continuous Administration of Sevoflurane Protects the Heart Against Ischemic Injury via Distinct Mitochondrial Mechanisms |
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| المؤلفون: | Christopher Lotz, Tobias Tischer-Zeitz, Anja Frank, Jan Stumpner, Norbert Roewer, Thorsten M Smul |
| المصدر: | Circulation Research. 113 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Physiology, Cardiology and Cardiovascular Medicine |
| الوصف: | Sevoflurane induced cardioprotection against ischemia/reperfusion (I/R) injury represents a well-established phenomenon. Salutary effects of the volatile anesthetic are not only limited to pre- or post-ischemic use, but clinical data also indicate its continuous administration as a beneficial mean. We investigated the hypothesis that the administration of sevoflurane during I/R-injury results in cardioprotection via the recruitment of distinct mitochondrial mechanisms. After IRB approval New Zealand White rabbits (9-12 weeks of age) received sevoflurane (1.0 MAC) or propofol (10 mg/kg/h) during 30 min of coronary artery occlusion followed by 3 h of reperfusion (n=7 per group). Cardiac mitochondria were isolated at the end of reperfusion. TTC-staining was used to determine the myocardial infarct size; in addition, mitochondrial O2 consumption was quantified and expressed as the respiratory control ratio (RCR). Mitochondrial electron transport chain (ETC) complex activities (I-IV) were assayed; including the analysis of an active to dormant (A/D) ratio of complex I. Statistics: ANOVA followed by posthoc Bonferroni, Mean ± SD. Our data indicate a significant infarct size reduction in animals receiving sevoflurane throughout the I/R-injury (p |
| تدمد: | 1524-4571 0009-7330 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::f0cd2975d14369c6149f9818e06ad38cTest https://doi.org/10.1161/res.113.suppl_1.a101Test |
| رقم الانضمام: | edsair.doi...........f0cd2975d14369c6149f9818e06ad38c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244571 00097330 |
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