Redox-Resistant SERCA [Sarco(endo)plasmic Reticulum Calcium ATPase] Attenuates Oxidant-Stimulated Mitochondrial Calcium and Apoptosis in Cardiac Myocytes and Pressure Overload-Induced Myocardial Failure in Mice.

التفاصيل البيبلوغرافية
العنوان:	Redox-Resistant SERCA [Sarco(endo)plasmic Reticulum Calcium ATPase] Attenuates Oxidant-Stimulated Mitochondrial Calcium and Apoptosis in Cardiac Myocytes and Pressure Overload-Induced Myocardial Failure in Mice.
المؤلفون:	Goodman, Jena B, Qin, Fuzhong, Morgan, Robert J, Chambers, Jordan M, Croteau, Dominique, Siwik, Deborah A, Hobai, Ion, Panagia, Marcello, Luptak, Ivan, Bachschmid, Markus, Tong, XiaoYong, Pimentel, David R, Cohen, Richard A, Colucci, Wilson S
المصدر:	Circulation ; ISSN:1524-4539 ; Volume:142 ; Issue:25
بيانات النشر:	Atypon
سنة النشر:	2020
المجموعة:	PubMed Central (PMC)
مصطلحات موضوعية:	apoptosis, calcium, heart failure, mitochondria, myocytes, cardiac, sarcoplasmic reticulum
الوصف:	SERCA [sarco(endo)plasmic reticulum calcium ATPase] is regulated by oxidative posttranslational modifications at cysteine 674 (C674). Because sarcoplasmic reticulum (SR) calcium has been shown to play a critical role in mediating mitochondrial dysfunction in response to reactive oxygen species, we hypothesized that SERCA oxidation at C674 would modulate the effects of reactive oxygen species on mitochondrial calcium and mitochondria-dependent apoptosis in cardiac myocytes.
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
العلاقة:	https://doi.org/10.1161/CIRCULATIONAHA.120.048183Test; https://pubmed.ncbi.nlm.nih.gov/33076678Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752816Test/
DOI:	10.1161/CIRCULATIONAHA.120.048183
الإتاحة:	https://doi.org/10.1161/CIRCULATIONAHA.120.048183Test https://pubmed.ncbi.nlm.nih.gov/33076678Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752816Test/
رقم الانضمام:	edsbas.2C2A91F1
قاعدة البيانات:	BASE

View record in BASE

الوصف
DOI:	10.1161/CIRCULATIONAHA.120.048183