Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery
| العنوان: | Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery |
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| المؤلفون: | Jody J. Haigh, Patrik Verstreken, Ger M.J. Janssen, Diether Lambrechts, Peter Carmeliet, Paul M. H. Schiffers, Greet Vanhoutte, Massimiliano Mazzone, Carmen Ruiz de Almodovar, Hermann Rohrer, Jo G. R. De Mey, Gregorio E. Fazzi, Koen Poesen, Stefan Vinckier, Merlijn J. Meens, Annemie Van der Linden, Serena Zacchigna, Katarzyna Miskiewicz, Erik Storkebaum |
| المساهمون: | Promovendi CD, Ondersteunend personeel CD, Farmacologie & Toxicologie, Bedrijfsbureau CD, RS: CARIM School for Cardiovascular Diseases, Storkebaum, Erik, Ruiz De Almodovar, Carmen, Meens, Merlijn, Zacchigna, Serena, Mazzone, Massimiliano, Vanhoutte, Greet, Vinckier, Stefan, Miskiewicz, Katarzyna, Poesen, Koen, Lambrechts, Diether, Janssen, Ger M. J., Fazzi, Gregorio E., Verstreken, Patrik, Haigh, Jody, Schiffers, Paul M., Rohrer, Hermann, Van Der Linden, Annemie, De Mey, Jo G. R., Carmeliet, Peter |
| المصدر: | Circulation Circulation, 122(3), 273-U107. LIPPINCOTT WILLIAMS & WILKINS CIRCULATION |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Vascular Endothelial Growth Factor A, SYMPATHETIC-NERVOUS-SYSTEM, Vascular smooth muscle, muscle, SMOOTH-MUSCLE-CELLS, Gene Expression, Transgenic, Muscle, Smooth, Vascular, Neuroeffector junction, arteries, chemistry.chemical_compound, Mesenteric Arterie, Mice, Cardiovascular Disease, vasoconstriction, vascular endothelial growth factor, Medicine (all), nervous system, Gene Transfer Techniques, arterie, Autonomic Nervous System Disease, MESENTERIC-ARTERIES, VEGF, Common, Mesenteric Arteries, Vascular endothelial growth factor B, Vascular endothelial growth factor, Vascular endothelial growth factor A, DIFFERENTIATION, medicine.anatomical_structure, Lac Operon, Cardiovascular Diseases, SURVIVAL, Smooth, Cardiology and Cardiovascular Medicine, smooth, Signal Transduction, EXPRESSION, medicine.medical_specialty, Neuroeffector, Carotid Artery, Common, Mice, Transgenic, RATS, Internal medicine, Vascular, Physiology (medical), muscle, smooth, medicine, Animals, Autonomic Nervous System Diseases, Vascular Endothelial Growth Factor Receptor-1, Vascular Endothelial Growth Factor Receptor-2, Vascular Resistance, Vasoconstriction, ERYTHRODYSESTHESIA, RECEPTOR, business.industry, Animal, Biology and Life Sciences, Kinase insert domain receptor, Gene Transfer Technique, Endocrinology, chemistry, Vascular resistance, Human medicine, Carotid Artery, business |
| الوصف: | Background— Control of peripheral resistance arteries by autonomic nerves is essential for the regulation of blood flow. The signals responsible for the maintenance of vascular neuroeffector mechanisms in the adult, however, remain largely unknown. Methods and Results— Here, we report that VEGF ∂/∂ mice with low vascular endothelial growth factor (VEGF) levels suffer defects in the regulation of resistance arteries. These defects are due to dysfunction and structural remodeling of the neuroeffector junction, the equivalent of a synapse between autonomic nerve endings and vascular smooth muscle cells, and to an impaired contractile smooth muscle cell phenotype. Notably, short-term delivery of a VEGF inhibitor to healthy mice also resulted in functional and structural defects of neuroeffector junctions. Conclusions— These findings uncover a novel role for VEGF in the maintenance of arterial neuroeffector function and may help us better understand how VEGF inhibitors cause vascular regulation defects in cancer patients. |
| وصف الملف: | pdf; application/pdf |
| اللغة: | English |
| تدمد: | 0009-7322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869af034c9a5edf6c835c5019c41bc07Test https://hdl.handle.net/10067/883510151162165141Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....869af034c9a5edf6c835c5019c41bc07 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00097322 |
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