Rapid Determination of Meropenem in Biological Fluids by LC: Comparison of Various Methods for Sample Preparation and Investigation of Meropenem Stability
| العنوان: | Rapid Determination of Meropenem in Biological Fluids by LC: Comparison of Various Methods for Sample Preparation and Investigation of Meropenem Stability |
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| المؤلفون: | Kaili Anier, Karin Kipper, Juri Karjagin, Koit Herodes, Ivo Leito, Kersti Oselin |
| المصدر: | Chromatographia. 70:1423-1427 |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Chromatography, Chemistry, Organic Chemistry, Clinical Biochemistry, Urine, Biochemistry, High-performance liquid chromatography, Meropenem, Analytical Chemistry, Pharmacokinetics, medicine, Protein precipitation, Sample preparation, Quantitative analysis (chemistry), Antibacterial agent, medicine.drug |
| الوصف: | A rapid and sensitive LC-UV method was developed and validated for the determination of meropenem, in human plasma and urine. Meropenem retention time was 4.8 min. Method development was based on comparative analysis of different extraction methods published as well as careful study of meropenem stability in biological samples under different conditions. Best results in plasma sample preparation were obtained from protein precipitation with methanol. LOQ was 0.1 µg mL−1 for plasma and 1 µg mL−1 for urine samples. Meropenem in plasma has low stability at room temperature ( |
| تدمد: | 1612-1112 0009-5893 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::f52bc94722bad927e22d918af48db2d1Test https://doi.org/10.1365/s10337-009-1304-8Test |
| رقم الانضمام: | edsair.doi...........f52bc94722bad927e22d918af48db2d1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16121112 00095893 |
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