التفاصيل البيبلوغرافية
| العنوان: |
Expression and significance of jumonji domain-containing protein 2B and hypoxia inducible factor-1α in non-Hodgkin lymphoma tissues in children. (English) |
| المؤلفون: |
DIAO Yu-Qiao, WANG Jian, ZHU Xiu-Li, CHEN Jian, ZHENG Yu, JIANG Lian, LIU Yue-Ping, DAI Ruo-Heng, YAN Yi- Wei |
| المصدر: |
Chinese Journal of Contemporary Pediatrics; Nov2023, Vol. 25 Issue 11, p1150-1155, 6p |
| مصطلحات موضوعية: |
NON-Hodgkin's lymphoma, LACTATE dehydrogenase, HYPOXEMIA |
| مستخلص: |
Objective To investigate the expression and significance of jumonji domain-containing protein 2B (JMJD2B) and hypoxia-inducible factor-1α (HIF-1α) in non-Hodgkin's lymphoma (NHL) tissues in children. Methods Immunohistochemistry was used to detect the expression of JMJD2B and HIF-1α in lymph node tissue specimens from 46 children with NHL (observation group) and 24 children with reactive hyperplasia (control group). The relationship between JMJD2B and HIF-1α expression with clinicopathological characteristics and prognosis in children with NHL, as well as the correlation between JMJD2B and HIF-1α expression in NHL tissues, were analyzed. Results The positive expression rates of JMJD2B (87% vs 21%) and HIF-1α (83% vs 42%) in the observation group were higher than those in the control group (P<0.05). The expression of JMJD2B and HIF-1α was correlated with serum lactate dehydrogenase levels and the risk of international prognostic index in children with NHL (P<0.05). The expression of JMJD2B was positively correlated with the HIF-1α expression in children with NHL (rs=0.333, P=0.024). Conclusions JMJD2B and HIF-1α are upregulated in children with NHL, and they may play a synergistic role in the development of pediatric NHL. JMJD2B can serve as a novel indicator for auxiliary diagnosis, evaluation of the severity, treatment guidance, and prognosis assessment in pediatric NHL. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
