Expression of SV40 Tag and formation Tag-p53 and Tag-Rb complexes in Chinese brain tumors
| العنوان: | Expression of SV40 Tag and formation Tag-p53 and Tag-Rb complexes in Chinese brain tumors |
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| المؤلفون: | Xianzhen Liu, Xiang Zhang, Jingwen Liang, Sheng-yu Yi, Xing-yao Bu, Hai-ning Zhen |
| المصدر: | Chinese Journal of Cancer Research. 13:18-21 |
| بيانات النشر: | Chinese Journal of Cancer Research, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Cancer Research, Pathology, medicine.medical_specialty, medicine.diagnostic_test, Pineocytoma, Brain tumor, Human brain, Biology, medicine.disease_cause, medicine.disease, Silver stain, medicine.anatomical_structure, Oncology, Antigen, Western blot, medicine, Cancer research, Choroid plexus, Carcinogenesis |
| الوصف: | Objective: To investigate the expression of SV40 Tag and formation of Tag-p53 and Tag-Rb complexes in Chinese brain tumors. Methods: SV40 large tumor antigen (Tag) were investigated by immunoprecipitation, silver staining and Western blot in 65 cases of Chinese brain tumors and 8 cases of normal brain tissues. Tag-p53 and Tag-Rb complexes were screened by the same way in 20 and 15 Tag positive tumor tissues respectively. Results: Tag was found in all of 8 ependymomas and 2 choroid plexus papillomas, 90% (9/10) of pituitary adenomas, 73% (11/15) of astrocytomas, 70% (7/10) of meningiomas, 50% (4/8) of glioblastoma multiform, 33% (2/6) of medulloblastomas, 5 oligodendrogliomas, 1 pineocytoma and 8 normal brain tissues were negative for Tag. Tag-p53 complex was detected in all of 20 Tag positive tumors as well as Tag-Rb complex in all of 15 Tag positive tumors. Conclusion: SV40 Tag is not only expressed in human brain tumors, but also it can form specific complexes with tumor suppressors p53 and Rb. SV40 is correlated to human brain tumorigenesis. The inactivation of p53 and Rb due to the formation of Tag-p53 and Tag-Rb complexes is possibly an important mechanism in the etiopathogenesis of human brain tumors. |
| تدمد: | 1993-0631 1000-9604 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::53317e20c3eee63ad118912b2b6fcc8eTest https://doi.org/10.1007/s11670-001-0005-0Test |
| رقم الانضمام: | edsair.doi...........53317e20c3eee63ad118912b2b6fcc8e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19930631 10009604 |
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