التفاصيل البيبلوغرافية
| العنوان: |
Brønsted acid-promoted ‘on–water’ C(sp3)-H functionalization for the synthesis of isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine derivatives targeting the SKP2-CKS1 interaction |
| المؤلفون: |
Yuan, Shuo, Wang, Sixi, Zhao, Min, Zhang, Danqing, Chen, Jinjie, Li, Jian-Xin, Zhang, Jingya, Song, Yihui, Wang, Jinyi, Yu, Bin, Liu, Hongmin |
| المصدر: |
Chinese Chemical Letters; February 2020, Vol. 31 Issue: 2 p349-352, 4p |
| مستخلص: |
New isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine derivatives were efficiently synthesized in good to excellent yields through the Brønsted acid-promoted ‘on–water’ C(sp3)-H functionalization and capable of inhibiting the SKP2-CKS1 interaction. The title compounds could be used as hit compounds to design more potent small–molecule inhibitors targeting the SKP2-CKS1 interaction. |
| قاعدة البيانات: |
Supplemental Index |
