التفاصيل البيبلوغرافية
| العنوان: |
Soluble leukocyte selectin in the analysis of pleural effusions. |
| المؤلفون: |
Horvath, Lynn Longmore, Gallup, Roger A., Worley, Brian D., Merrill, Gerald A., Morris, Michael J., Horvath, L L, Gallup, R A, Worley, B D, Merrill, G A, Morris, M J |
| المصدر: |
CHEST; Aug2001, Vol. 120 Issue 2, p362-368, 7p, 4 Charts, 2 Graphs |
| مصطلحات موضوعية: |
LEUCOCYTES, BODY fluid analysis, PLEURAL effusions, EXUDATES & transudates, BIOMARKERS |
| مستخلص: |
Study Objectives: To determine if soluble leukocyte selectin (sL-selectin) levels in serum and pleural fluid (PF) are an inflammatory marker that differentiates pleural effusion transudates from exudates.Design: sL-selectin PF and serum levels were measured in consecutive patients and compared to established criteria.Setting: A tertiary-care military medical center.Patients: One hundred twenty patients undergoing diagnostic or therapeutic thoracentesis.Interventions: PF and serum samples were collected during thoracentesis and analyzed separately for sL-selectin levels. Results were compared with clinical diagnosis and established PF criteria including the criteria of Light et al, cholesterol ratio, total bilirubin ratio, and albumin gradient.Measurements and Results: sL-selectin levels in PF and serum were determined in 109 patients. By clinical diagnosis, mean +/- SD PF sL-selectin levels were 200.2 +/- 124.3 ng/mL in transudates and 496.8 +/- 379.2 ng/mL in exudates (p < 0.001). By the criteria of Light et al, mean PF sL-selectin levels were 195.7 +/- 105.2 ng/mL in transudates and 448.2 +/- 367.6 ng/mL in exudates (p < 0.001). Mean sL-selectin PF to serum ratios were 0.31 +/- 0.17 in transudates and 0.72 +/- 0.31 in exudates (p < 0.001) by clinical criteria, and 0.31 +/- 0.18 in transudates and 0.64 +/- 0.33 in exudates (p < 0.001) by the criteria of Light et al. No significant difference was noted with serum sL-selectin levels between groups.Conclusions: sL-selectin is an inflammatory marker that differentiates transudates from exudates in pleural effusions and is a sensitive indicator for PF analysis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
