التفاصيل البيبلوغرافية
| العنوان: |
Potent in vitro Activity of the Albumin Fusion Type 1 Interferons (Albumin-Interferon-Alpha and Albumin-Interferon-Beta) against RNA Viral Agents of Bioterrorism and the Severe Acute Respiratory Syndrome (SARS) Virus. |
| المؤلفون: |
Subramanian, G. Mani1 Mani_Subramanian@hgsi.com, Moore, Paul A.1, Gowen, Brian B.2, Olsen, Aaron L.2, Barnard, Dale L.2, Paragas, Jason3, Hogan, Robert J.4, Sidwell, Robert W.2 |
| المصدر: |
Chemotherapy (0009-3157). 2008, Vol. 54 Issue 3, p176-180. 5p. 1 Chart, 2 Graphs. |
| مصطلحات موضوعية: |
*ALBUMINS, *GENETICS, *RESPIRATORY diseases, *ANTIVIRAL agents, *BIOTERRORISM |
| مستخلص: |
Background: The type 1 interferons (INF-α and INF-β) are potent antiviral agents. Albumin-INF-α and albumin-INF-β are novel recombinant proteins consisting of IFN-α or IFN-β genetically fused to human albumin. Methods: The in vitro antiviral activity of albumin-IFN-α was evaluated against representative bioterrorism viral agents and the severe acute respiratory syndrome virus. Antiviral activity was assessed using inhibition of cytopathic effect and neutral red staining. Results: EC50 values for albumin-IFN-α ranged from <0.1 ng/ml for Punta Toro virus to 65 ng/ml for Venezuelan equine encephalitis virus in the neutral red assay. Albumin-IFN-β showed 75- and 360-fold greater in vitro activity than albumin-IFN-α against Ebola virus and severe acute respiratory syndrome, respectively. Conclusion: Further evaluation of these long-acting albumin-IFN fusion proteins as prophylactic or therapeutic agents against these viral agents of bioterrorism in relevant primate models is warranted. Copyright © 2008 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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