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1
المؤلفون: John Gatfield, Catherine Roch, Thierry Sifferlen, Jodi T. Williams, Alexander Treiber, Christoph Boss, Martin Bolli, Christine Brotschi, Bibia Heidmann, Francois Jenck
المصدر: ChemMedChem. 14:1257-1270
مصطلحات موضوعية: Oxadiazole, Pharmacology, 01 natural sciences, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Orexin Receptors, Drug Discovery, Animals, Cytochrome P-450 CYP3A, Humans, General Pharmacology, Toxicology and Pharmaceutics, Receptor, Oxadiazoles, CYP3A4, 010405 organic chemistry, Organic Chemistry, Suvorexant, Antagonist, Azepines, Triazoles, Orexin receptor, Rats, 0104 chemical sciences, Orexin, 010404 medicinal & biomolecular chemistry, chemistry, Molecular Medicine, Orexin Receptor Antagonists, Wakefulness, Sleep, Half-Life
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b115f7c0f955cf770604ab0fdaa3d44Test
https://doi.org/10.1002/cmdc.201900242Test -
2
المؤلفون: Henri Xhaard, Erik A.A. Wallén, Jari Yli-Kauhaluoma, Jyrki P. Kukkonen, Teppo O. Leino, Lasse Karhu, Ainoleena Turku
المصدر: ChemMedChem. 14:965-981
مصطلحات موضوعية: Pharmacology, Indole test, Agonist, Bicyclic molecule, 010405 organic chemistry, Stereochemistry, Chemistry, medicine.drug_class, Organic Chemistry, Biological activity, Potentiator, 01 natural sciences, Biochemistry, Orexin receptor, 0104 chemical sciences, 3. Good health, Orexin, 010404 medicinal & biomolecular chemistry, mental disorders, Drug Discovery, medicine, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics, Binding site, psychological phenomena and processes
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::61323be3ae0c6af0b57567aabae3d334Test
https://doi.org/10.1002/cmdc.201900074Test -
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المؤلفون: Markus von Raumer, Bibia Heidmann, Christoph Boss, John Gatfield, Catherine Roch, Jodi T. Williams, Christine Brotschi, Alexander Treiber, Thierry Sifferlen, Gunther Schmidt
المصدر: ChemMedChem. 15(23)
مصطلحات موضوعية: Pyrrolidines, media_common.quotation_subject, Doras, 01 natural sciences, Biochemistry, Orexin-A, Orexin Receptors, Sleep Initiation and Maintenance Disorders, mental disorders, Drug Discovery, Medicine, Humans, General Pharmacology, Toxicology and Pharmaceutics, Receptor, media_common, G protein-coupled receptor, Pharmacology, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, business.industry, Addiction, digestive, oral, and skin physiology, Organic Chemistry, Imidazoles, medicine.disease, biology.organism_classification, Orexin receptor, 0104 chemical sciences, Orexin, 010404 medicinal & biomolecular chemistry, Eating disorders, nervous system, Molecular Medicine, Orexin Receptor Antagonists, business, Neuroscience, hormones, hormone substitutes, and hormone antagonists, psychological phenomena and processes
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a288d5cb5ef111945479c378d0102354Test
https://pubmed.ncbi.nlm.nih.gov/32937014Test -
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المؤلفون: Martin Bolli, Jodi T. Williams, John Gatfield, Thierry Sifferlen, Francois Jenck, Christine Brotschi, Alexander Treiber, Christoph Boss, Catherine Roch, Bibia Heidmann
المصدر: ChemMedChem. 15(5)
مصطلحات موضوعية: Male, Triazole, Molecular Conformation, Oxadiazole, Pharmacology, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Dogs, In vivo, Orexin Receptors, Drug Discovery, Animals, General Pharmacology, Toxicology and Pharmaceutics, Rats, Wistar, Oxadiazoles, 010405 organic chemistry, Organic Chemistry, Suvorexant, Antagonist, Stereoisomerism, Triazoles, Orexin receptor, 0104 chemical sciences, Orexin, Rats, 010404 medicinal & biomolecular chemistry, chemistry, Free fraction, Molecular Medicine, Orexin Receptor Antagonists, Sleep
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d792ebd1ec5cf2b266a54e3654ee9858Test
https://pubmed.ncbi.nlm.nih.gov/31945272Test -
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المؤلفون: Jodi T. Williams, Alexander Treiber, Christine Brotschi, Thierry Sifferlen, John Gatfield, Catherine Roch, Christoph Boss, Bibia Heidmann, Markus von Raumer, Gunther Schmidt
المصدر: ChemMedChem. 15:2206-2206
مصطلحات موضوعية: Pharmacology, business.industry, Orexin Receptor Antagonists, Organic Chemistry, Antagonist, Biochemistry, Orexin receptor, Front cover, Drug Discovery, Molecular Medicine, Medicine, General Pharmacology, Toxicology and Pharmaceutics, business, Insomnia Disorders, G protein-coupled receptor
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::189b5bafe28dedff25c91c1b35fca66fTest
https://doi.org/10.1002/cmdc.202000881Test -
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المؤلفون: Thierry Sifferlen, Simone Tortoioli, Jodi T. Williams, Christoph Boss, Bibia Heidmann, Francois Jenck, Catherine Roch, Martin Bolli, Alexander Treiber, Stefan Abele, Christine Brotschi, John Gatfield
المصدر: ChemMedChem. 11:2132-2146
مصطلحات موضوعية: Male, 0301 basic medicine, Pharmacology, 01 natural sciences, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, Dogs, Orexin Receptors, Drug Discovery, Animals, Cytochrome P-450 CYP3A, Humans, Structure–activity relationship, Rats, Wistar, General Pharmacology, Toxicology and Pharmaceutics, Receptor, Cytochrome P-450 CYP3A Inhibitors, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Drug discovery, Organic Chemistry, Suvorexant, Cytochrome P450, Orexin receptor, Rats, 0104 chemical sciences, Orexin, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Microsomes, Liver, biology.protein, Molecular Medicine, Orexin Receptor Antagonists, Sleep
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80705be334fa821846eec87b286c5943Test
https://doi.org/10.1002/cmdc.201600175Test -
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المؤلفون: Catherine Roch-Brisbare, Jodi T. Williams, Thierry Sifferlen, Christine Brotschi, John Gatfield, Michel A. Steiner, Hamed Aissaoui, Christoph Boss, Francois Jenck, Markus von Raumer, Alexander Treiber, Bibia Heidmann, Romain Siegrist, Hendrik Dietrich
المصدر: ChemMedChem. 9:2486-2496
مصطلحات موضوعية: Male, Pyrrolidines, Proline, Lateral hypothalamus, Pharmacology, Biochemistry, Madin Darby Canine Kidney Cells, Structure-Activity Relationship, Orexin-A, Dogs, Orexin Receptors, mental disorders, Drug Discovery, medicine, Animals, Humans, Rats, Wistar, General Pharmacology, Toxicology and Pharmaceutics, Receptor, Neurotransmitter Agents, Sulfonamides, Chemistry, digestive, oral, and skin physiology, Organic Chemistry, Suvorexant, Brain, Stereoisomerism, Orexin receptor, Rats, Orexin, nervous system, Blood-Brain Barrier, Molecular Medicine, Orexin Receptor Antagonists, Wakefulness, Almorexant, hormones, hormone substitutes, and hormone antagonists, psychological phenomena and processes, Half-Life, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d65f7c32c5749e718e69e9d3d6285c4Test
https://doi.org/10.1002/cmdc.201402258Test -
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المؤلفون: John J. Renger, Chunze Li, Michael J. Bogusky, Yuxing Li, Scott M. Doran, David B. Whitman, Wei Lemaire, John D. Schreier, Joseph G. Bruno, Karen M. Brashear, Duane R. Reiss, Thomayant Prueksaritanont, Rodney A. Bednar, C. Meacham Harrell, Susan L. Garson, Paul J. Coleman, Richard L. Kraus, Christopher D. Cox, George D. Hartman, Kenneth S. Koblan, Michael J. Breslin, Christopher J. Winrow
المصدر: ChemMedChem. 4:1069-1074
مصطلحات موضوعية: Central Nervous System, Receptors, Neuropeptide, Sleep Wake Disorders, medicine.medical_specialty, Pharmacology, Biochemistry, Receptors, G-Protein-Coupled, Structure-Activity Relationship, Orexin Receptors, In vivo, Oral administration, Internal medicine, mental disorders, Drug Discovery, medicine, Animals, General Pharmacology, Toxicology and Pharmaceutics, Chemistry, digestive, oral, and skin physiology, Organic Chemistry, Antagonist, Azepines, Sleep in non-human animals, Orexin receptor, Rats, Orexin, Endocrinology, nervous system, Molecular Medicine, Wakefulness, Antagonism, psychological phenomena and processes
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66d6f4c7866f587c095e4844466f8a6Test
https://doi.org/10.1002/cmdc.200900069Test -
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المؤلفون: Anthony J. Roecker, Tamara D. Cabalu, Mark E. Fraley, Thomayant Prueksaritanont, John J. Renger, Paul J. Coleman, Wei Lemaire, Pamela L. Tannenbaum, Joseph G. Bruno, Steven V. Fox, Susan L. Garson, Christopher D. Cox, Christopher J. Winrow, Anthony L. Gotter, Joyce Stellabott, John D. Schreier, Donghui Cui, George D. Hartman, Swati P. Mercer, Justin T. Steen, Joanne Stevens, Steven D. Young, C. Meacham Harrell
المصدر: ChemMedChem. 9(2)
مصطلحات موضوعية: Male, medicine.drug_class, Pyridines, Carboxamide, Pharmacology, Biochemistry, Rats, Sprague-Dawley, Mice, Dogs, In vivo, Sleep Initiation and Maintenance Disorders, Drug Discovery, medicine, Animals, Humans, General Pharmacology, Toxicology and Pharmaceutics, Receptor, Orexins, Chemistry, Organic Chemistry, Suvorexant, Neuropeptides, Antagonist, Intracellular Signaling Peptides and Proteins, Macaca mulatta, Orexin receptor, Orexin, Rats, Mice, Inbred C57BL, Drug Design, Molecular Medicine, Orexin antagonist
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a2d2b9b49468481cfcb53f86059feeTest
https://pubmed.ncbi.nlm.nih.gov/24376006Test -
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المؤلفون: Hendrik Dietrich, John Gatfield, Michel A. Steiner, Catherine Brisbare-Roch, Alexander Treiber, Francois Jenck, Christoph Boss
المصدر: ChemMedChem. 8(6)
مصطلحات موضوعية: medicine.medical_specialty, Benzeneacetamides, Neuropeptide, Administration, Oral, Pharmacology, Biochemistry, Arousal, chemistry.chemical_compound, Structure-Activity Relationship, Orexin Receptors, Internal medicine, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, General Pharmacology, Toxicology and Pharmaceutics, Dose-Response Relationship, Drug, Chemistry, Drug discovery, Organic Chemistry, Antagonist, Brain, Isoquinolines, Orexin receptor, Orexin, Rats, Endocrinology, Molecular Medicine, Orexin Receptor Antagonists, Penetrant (biochemical)
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f522976865e88cba7f0be255780b9cbTest
https://pubmed.ncbi.nlm.nih.gov/23589487Test