التفاصيل البيبلوغرافية
| العنوان: |
A new isoflavone derivative from Streptomyces sp. YIM GS3536. |
| المؤلفون: |
Huang, Rong, Ding, Zhang-Gui, Long, Yun-Feng, Zhao, Jiang-Yuan, Li, Ming-Gang, Cui, Xiao-Long, Wen, Meng-Liang |
| المصدر: |
Chemistry of Natural Compounds; Jan2013, Vol. 48 Issue 6, p966-969, 4p, 1 Chart |
| مصطلحات موضوعية: |
ISOFLAVONES, STREPTOMYCES, NATURAL products, NUCLEAR magnetic resonance spectroscopy, CELL lines, BACILLUS subtilis |
| مستخلص: |
A new natural product named 7-O-methyl-8-chlorogenistein ( 1) was isolated together with eight known isoflavones, 8-chlorogenistein ( 2), kakkatin ( 3), 7-O-methyl genistein ( 4), genistein ( 5), daidzein ( 6), glycitin ( 7), genistin ( 8), and daidzin ( 9), from the metabolites of Streptomyces strain YIM GS3536, which was isolated from soil sample collected from Yunnan Province, China. We report the unambiguous assignments of the H and C NMR spectra of the new compound 7-O-methyl-8-chlorogenistein ( 1). Compound 1 exhibited appreciable cytotoxicity against human melanoma cell lines (B16) and human leukemia cell lines (HL60) with IC values of 17.5 and 19.2 μM, respectively. The MIC values of 1 for Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Candida albicans were in the range of 23-35 μM. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
