التفاصيل البيبلوغرافية
| العنوان: |
Facile Synthesis of Multifunctional Germanium Nanoparticles as a Carrier of Quercetin to Achieve Enhanced Biological Activity. |
| المؤلفون: |
Guo, Yan ‐ Jie, Yang, Fen, Zhang, Lu, Pi, Jiang, Cai, Ji ‐ Ye, Yang, Pei ‐ Hui |
| المصدر: |
Chemistry - An Asian Journal; Aug2014, Vol. 9 Issue 8, p2272-2280, 9p |
| مصطلحات موضوعية: |
QUERCETIN, GERMANIUM, NANOSTRUCTURED materials, NANOPARTICLES, POLYPHENOLS |
| مستخلص: |
A simple method for preparing quercetin surface-functionalized germanium nanoparticles (Qu-GeNPs) with enhanced antioxidant and anticancer activity is reported. Spherical germanium nanoparticles (GeNPs) were capped by quercetin (Qu) with a mean particle size of approximately 33 nm and were characterized by TEM, AFM, UV-visible absorption spectroscopy, FTIR, and XRD measurements. The in vitro drug release of Qu from the Qu-GeNPs indicated that Qu could principally be distributed around tumor tissues rather than in the normal section and Qu-GeNPs were internalized by MCF-7 cells. Their biological activity test results indicated that these Qu-GeNPs possessed stronger hydroxyl-scavenging effects and proliferative inhibition effect on MCF-7 cancer cells than quercetin, thus suggesting that the strategy to use GeNPs as a carrier of Qu could be an efficient way to achieve enhanced antioxidant and anticancer activity. In addition, Qu-GeNPs possessed a high apoptotic induction effect in cancer cells, especially in high dosages, and could arrest MCF-7 cells in the S phase. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
