التفاصيل البيبلوغرافية
| العنوان: |
Hydrogel and Organogel Formation by Hierarchical Self‐Assembly of Cyclic Peptides Nanotubes. |
| المؤلفون: |
Shaikh, Huda, Rho, Julia Y., Macdougall, Laura J., Gurnani, Pratik, Lunn, Andrew M., Yang, Jie, Huband, Steve, Mansfield, Edward D. H., Peltier, Raoul, Perrier, Sebastien |
| المصدر: |
Chemistry - A European Journal; 12/17/2018, Vol. 24 Issue 71, p19066-19074, 9p |
| مصطلحات موضوعية: |
HYDROGELS, CYCLIC peptides, NANOTUBES, X-ray scattering, GELATION |
| مستخلص: |
Breaking away from the linear structure of previously reported peptide‐based gelators, this study reports the first example of gel formation based on the use of cyclic peptides made of alternating d‐ and l‐amino acids, known to self‐assemble in solution to form long nanotubes. Herein, a library of cyclic peptides was systemically studied for their gelation properties in various solvents, uncovering key parameters driving both organogel and hydrogel formation. The hierarchical nature of the self‐assembly process in water was characterised by a combination of electron microscopy imaging and small‐angle X‐ray scattering, revealing a porous network of entangled nanofibres composed by the aggregation of several cyclic peptide nanotubes. Rheology measurements then confirmed the formation of soft hydrogels. Getting in formation: This study reports the first example of gel formation based on the use of cyclic peptides made of alternating d‐ and l‐ amino acids, which self‐assemble in solution to form long nanotubes. Herein, a library of cyclic peptides was systemically studied for their gelation properties in various solvents, uncovering key parameters driving both organogel and hydrogel formation. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
