Antioxidants in Chinese Herbal Medicines: A Biochemical Perspective
| العنوان: | Antioxidants in Chinese Herbal Medicines: A Biochemical Perspective |
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| المؤلفون: | J. Sun, Shan Hong Huang, Yi Zhun Zhu, Matthew Whiteman, Y.-C. Zhu, B. K. H. Tan |
| المصدر: | ChemInform. 35 |
| بيانات النشر: | Wiley, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Antioxidant, DPPH, medicine.medical_treatment, Context (language use), Pharmacology, Biochemistry, Salvia miltiorrhiza, Antioxidants, Lipid peroxidation, Superoxide dismutase, chemistry.chemical_compound, Drug Discovery, medicine, chemistry.chemical_classification, Plants, Medicinal, ABTS, Molecular Structure, biology, Traditional medicine, Chemistry, Glutathione peroxidase, Organic Chemistry, Perspective (graphical), General Medicine, biology.protein, Drugs, Chinese Herbal |
| الوصف: | Recently, intense interest has focused on the antioxidant properties of natural products. In particular, Chinese herbal medicines (CHM) have become hot topics for life science researchers since many are reported to possess cardioprotective compounds, many of which remain to be identified. Indeed, the exact mechanisms by which CHM work remain unknown. Although many of these herbal remedies are undoubtedly efficacious, few have been scientifically investigated for their active chemical constituents and biological activities. We have previously reported higher activities of antioxidant defence enzymes such as superoxide dismutase, catalase, glutathione peroxidase and glutathione S-transferases in the liver of rats treated with the herb Salvia miltiorrhiza in a model of acute myocardial infarction. Using well established in vitro antioxidant assays employing 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) and diphenyl-l-picrylhydrazyl (DPPH) we have shown that in addition to elevating endogenous antioxidant enzyme activity, Salvia miltiorrhiza and other CHM traditionally used for cardiovascular disorders (such as Rhizoma ligustici, Herba leonuri, Radix achyranthis bidentatae, and Camellia sinensis) contain potent antioxidant moieties in addition to their phenolic constituents. Furthermore, these novel non-phenolic components are effective inhibitors of oxidative reactions mediated by the inflammatory oxidants, peroxynitrite,hypochlorous acid and hydroxyl radical as well as iron-dependent lipid peroxidation. In this review, we discuss the various antioxidant properties of CHM in the context of their biochemical mechanisms. |
| تدمد: | 1522-2667 0931-7597 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a69d2dca38d224bd2f70390f25e2f2Test https://doi.org/10.1002/chin.200446293Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....96a69d2dca38d224bd2f70390f25e2f2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15222667 09317597 |
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