Aminoacyl-tRNA-Utilizing Enzymes in Natural Product Biosynthesis
| العنوان: | Aminoacyl-tRNA-Utilizing Enzymes in Natural Product Biosynthesis |
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| المؤلفون: | Mireille Moutiez, Muriel Gondry, Pascal Belin |
| المساهمون: | Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Enzymologie et Biosynthèse Peptidique Non Ribosomale (BIOSYN), Département Microbiologie (Dpt Microbio), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Chemical Reviews Chemical Reviews, 2017, ⟨10.1021/acs.chemrev.6b00523⟩ |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, chemistry.chemical_classification, Aminoacyl-tRNA, Biological Products, Natural product, Protein Conformation, [SDV]Life Sciences [q-bio], General Chemistry, Protein degradation, RNA, Transfer, Amino Acyl, Catalysis, Enzymes, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Enzyme, Protein structure, chemistry, Biochemistry, Biosynthesis, Protein biosynthesis, Secondary metabolism |
| الوصف: | Aminoacyl-tRNAs were long thought to be involved solely in ribosome-dependent protein synthesis and essential primary metabolism processes, such as targeted protein degradation and peptidoglycan synthesis. About 10 years ago, an aminoacyl-tRNA-dependent enzyme involved in the biosynthesis of the antibiotic valanimycin was discovered in a Streptomyces strain. Far from being an isolated case, this discovery has been followed by the description of an increasing number of aminoacyl-tRNA-dependent enzymes involved in secondary metabolism. This review describes the three groups of aminoacyl-tRNA-dependent enzymes involved in the synthesis of natural products. Each group is characterized by a particular chemical reaction, and its members are predicted to share a specific fold. The three groups are cyclodipeptide synthases involved in diketopiperazine synthesis, LanB-like dehydratases involved in the posttranslational modification of ribosomal peptides, and transferases from various biosynthesis pathways. |
| تدمد: | 1520-6890 0009-2665 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de38d36d80cdc9a4a40935e93fad15fTest https://pubmed.ncbi.nlm.nih.gov/28060488Test |
| رقم الانضمام: | edsair.doi.dedup.....2de38d36d80cdc9a4a40935e93fad15f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15206890 00092665 |
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