Atypical Endocannabinoid Signaling Initiates a New Form of Memory-Related Plasticity at a Cortical Input to Hippocampus
| العنوان: | Atypical Endocannabinoid Signaling Initiates a New Form of Memory-Related Plasticity at a Cortical Input to Hippocampus |
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| المؤلفون: | Christine M. Gall, Gary Lynch, Kwang-Mook Jung, Linda C. Palmer, Gavin Rumbaugh, Yousheng Jia, Daniele Piomelli, Weisheng Wang, Danielle T. Pham, Conor D. Cox |
| المصدر: | Cerebral cortex (New York, N.Y. : 1991), vol 28, iss 7 Wang, W; Jia, Y; Pham, DT; Palmer, LC; Jung, K-M; Cox, CD; et al.(2018). Atypical Endocannabinoid Signaling Initiates a New Form of Memory-Related Plasticity at a Cortical Input to Hippocampus. CEREBRAL CORTEX, 28(7), 2253-2266. doi: 10.1093/cercor/bhx126. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0bq5q49xTest |
| بيانات النشر: | Oxford University Press (OUP), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Cannabinoid receptor, medicine.medical_treatment, Hippocampus, Inbred C57BL, Rats, Sprague-Dawley, Mice, 0302 clinical medicine, Piperidines, Neural Pathways, Psychology, Enzyme Inhibitors, Episodic memory, pregnenolone, Cerebral Cortex, Mice, Knockout, Neurons, lateral perforant path, Experimental Psychology, Long-term potentiation, Endocannabinoid system, medicine.anatomical_structure, Pregnenolone, Cognitive Sciences, Signal Transduction, medicine.drug, GABA Agents, Knockout, Cognitive Neuroscience, Perceptual Disorders, 03 medical and health sciences, Cellular and Molecular Neuroscience, Munc18 Proteins, Memory, medicine, Animals, long-term potentiation, Neurosciences, Original Articles, Lipid Metabolism, Perforant path, Rats, Mice, Inbred C57BL, cannabinoid receptor 1, 030104 developmental biology, nervous system, Munc18-1, Pyrazoles, Sprague-Dawley, Cannabinoid, Neuroscience, 030217 neurology & neurosurgery, Endocannabinoids |
| الوصف: | Endocannabinoids (ECBs) depress transmitter release at sites throughout the brain. Here, we describe another form of ECB signaling that triggers a novel form of long-term potentiation (LTP) localized to the lateral perforant path (LPP) which conveys semantic information from cortex to hippocampus. Two cannabinoid CB(1) receptor (CB(1)R) signaling cascades were identified in hippocampus. The first is pregnenolone sensitive, targets vesicular protein Munc18-1 and depresses transmitter release; this cascade is engaged by CB(1)Rs in Schaffer–Commissural afferents to CA1 but not in the LPP, and it does not contribute to LTP. The second cascade is pregnenolone insensitive and LPP specific; it entails co-operative CB(1)R/β1-integrin signaling to effect synaptic potentiation via stable enhancement of transmitter release. The latter cascade is engaged during LPP-dependent learning. These results link atypical ECB signaling to the encoding of a fundamental component of episodic memory and suggest a novel route whereby endogenous and exogenous cannabinoids affect cognition. |
| وصف الملف: | application/pdf |
| تدمد: | 1460-2199 1047-3211 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436fd6dfadba7bbf52b1c62c9e9324a8Test https://doi.org/10.1093/cercor/bhx126Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....436fd6dfadba7bbf52b1c62c9e9324a8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602199 10473211 |
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