Brain areas with normatively greater cerebral perfusion in early life may be more susceptible to beta amyloid deposition in late life

التفاصيل البيبلوغرافية
العنوان: Brain areas with normatively greater cerebral perfusion in early life may be more susceptible to beta amyloid deposition in late life
المؤلفون: Meier, Irene B., Lao, Patrick J., Gietl, Anton, Vorburger, Robert S., Gutierrez, José, Holland, Christopher M., Guttmann, Charles R.G., Meier, Dominik S., Buck, Alfred, Nitsch, Roger M., Hock, Christoph, Unschuld, Paul G., Brickman, Adam M.
المصدر: Cerebral Circulation - Cognition and Behavior; January 2020, Vol. 1 Issue: 1
مستخلص: •Brain areas with higher neuronal activity and metabolic demand in early life may contribute to higher beta amyloid deposition later in life.•The spatial relationship between normative perfusion patterns in young individuals and amyloid pathophysiology in older individuals were assessed.•Brain areas with normatively greater perfusion may be more susceptible to amyloid deposition in later life.
قاعدة البيانات: Supplemental Index
الوصف
تدمد:26662450
DOI:10.1016/j.cccb.2020.100001