دورية أكاديمية
Phenotypical changes of hematopoietic stem and progenitor cells in COVID-19 patients: Correlation with disease status
| العنوان: | Phenotypical changes of hematopoietic stem and progenitor cells in COVID-19 patients: Correlation with disease status |
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| المؤلفون: | Hosni A. M. Hussein, Ali A. A. Thabet, Taha I. A. Mohamed, Mohamed E. Elnosary, Ali Sobhy, Ahmed M. El-Adly, Ahmed A. Wardany, Elsayed K. Bakhiet, Magdy M. Afifi, Usama M. Abdulraouf, Samah . M. Fathy, Noha G. Sayed, Asmaa M. Zahran |
| المصدر: | Central European Journal of Immunology, Vol 48, Iss 2, Pp 97-110 (2023) |
| بيانات النشر: | Termedia Publishing House, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | covid-19, sars-cov-2, hematopoietic stem cells (hscs), hematopoietic progenitor cells (hpcs), Medicine |
| الوصف: | Hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) play a crucial role in the context of viral infections and their associated diseases. The link between HSCs and HPCs and disease status in COVID-19 patients is largely unknown. This study aimed to monitor the kinetics and contributions of HSCs and HPCs in severe and non-severe COVID-19 patients and to evaluate their diagnostic performance in differentiating between healthy and COVID-19 patients as well as severe and non-severe cases. Peripheral blood (PB) samples were collected from 48 COVID-19 patients, 16 recovered, and 27 healthy controls and subjected to deep flow cytometric analysis to determine HSCs and progenitor cells. Their diagnostic value and correlation with C-reactive protein (CRP), D-dimer, and ferritin levels were determined. The percentages of HSCs and common myeloid progenitors (CMPs) declined significantly, while the percentage of multipotent progenitors (MPPs) increased significantly in COVID-19 patients. There were no significant differences in the percentages of megakaryocyte-erythroid progenitors (MEPs) and granulocyte-macrophage progenitors (GMPs) between all groups. Severe COVID-19 patients had a significantly low percentage of HSCs, CMPs, and GMPs compared to non-severe cases. Contrarily, the levels of CRP, D-dimer, and ferritin increased significantly in severe COVID-19 patients. MPPs and CMPs showed excellent diagnostic performance in distinguishing COVID-19 patients from healthy controls and severe from non-severe COVID-19 patients, respectively. Collectively, our study indicated that hematopoietic stem and progenitor cells are significantly altered by COVID-19 and could be used as therapeutic targets and diagnostic biomarkers for severe COVID-19. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1426-3912 1644-4124 |
| العلاقة: | https://www.termedia.pl/Phenotypical-changes-of-hematopoietic-stem-r-nand-progenitor-cells-in-COVID-19-patients-r-nCorrelation-with-disease-status,10,51130,1,1.htmlTest; https://doaj.org/toc/1426-3912Test; https://doaj.org/toc/1644-4124Test |
| DOI: | 10.5114/ceji.2023.129981 |
| الوصول الحر: | https://doaj.org/article/1feeaa1b6dff4fcca05b29c58182255bTest |
| رقم الانضمام: | edsdoj.1feeaa1b6dff4fcca05b29c58182255b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14263912 16444124 |
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| DOI: | 10.5114/ceji.2023.129981 |