Human β-defensins
| العنوان: | Human β-defensins |
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| المؤلفون: | Jacek Lubkowski, Wuyuan Lu, D. M. Hoover, De Yang, Marzena Pazgier |
| المصدر: | Cellular and Molecular Life Sciences CMLS. 63:1294-1313 |
| بيانات النشر: | Springer Science and Business Media LLC, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Pharmacology, integumentary system, fungi, Cell Biology, Computational biology, respiratory system, Biology, Bioinformatics, Cellular and Molecular Neuroscience, Sequence homology, Protein structure, Molecular Medicine, Genomic information, Human genome, Molecular Biology, Transcription factor, Gene, Function (biology) |
| الوصف: | The last decade led to the discovery and characterization of several human β-defensins. Analysis of genomic information indicates that the number of β-defensin-like molecules encoded by the human genome may number in the tens. Growing interest in β-defensins steadily enhances our knowledge about various aspects of their gene location, expression patterns and the transcription factors involved in their regulation in vivo. The hallmark property of β-defensins, their antimicrobial activity, is clearly only the tip of the iceberg in the extensive network of inter-relations within the immune system in which these peptides function. Structural studies of β-defensins provide the molecular basis for a better understanding of their properties, functions and their potential for practical applications. In this review, we present some recent advances in the studies of human β-defensins, with an emphasis on possible correlations between their structural and functional properties. |
| تدمد: | 1420-9071 1420-682X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::c380d90b4890409611f48bf85f194880Test https://doi.org/10.1007/s00018-005-5540-2Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........c380d90b4890409611f48bf85f194880 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14209071 1420682X |
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