Microglia and inflammation: conspiracy, controversy or control?
| العنوان: | Microglia and inflammation: conspiracy, controversy or control? |
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| المؤلفون: | Leonor Miller-Fleming, Teresa F. Pais, Adelaide Fernandes |
| المصدر: | Cellular and Molecular Life Sciences. 71:3969-3985 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Transcriptional Activation, Central nervous system, Inflammation, Disease, Biology, Pathogenesis, Cellular and Molecular Neuroscience, Central Nervous System Diseases, Neuroplasticity, medicine, Animals, Humans, Molecular Biology, Pharmacology, Neuronal Plasticity, Innate immune system, Microglia, Macrophages, Anti-Inflammatory Agents, Non-Steroidal, Cell Biology, medicine.anatomical_structure, nervous system, Blood-Brain Barrier, Immunology, Molecular Medicine, medicine.symptom, Neuroscience, Homeostasis, Signal Transduction |
| الوصف: | Microglial cells contribute to normal function of the central nervous system (CNS). Besides playing a role in the innate immunity, they are also involved in neuronal plasticity and homeostasis of the CNS. While microglial cells get activated and undergo phenotypic changes in different disease contexts, they are far from being the "villains" in the CNS. Mounting evidence indicates that microglial dysfunction can exacerbate the pathogenesis of several diseases in the CNS. Several molecular mechanisms tightly regulate the production of inflammatory and toxic factors released by microglia. These mechanisms involve the interaction with other glial cells and neurons and the fine regulation of signaling and transcription activation pathways. The purpose of this review is to discuss microglia activation and to highlight the molecular pathways that can counteract the detrimental role of microglia in several neurologic diseases. Recent work presented in this review support that the understanding of microglial responses can pave the way to design new therapies for inflammatory diseases of the CNS. |
| تدمد: | 1420-9071 1420-682X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3f768c9bb9ac7ef9a51e6548b42a29Test https://doi.org/10.1007/s00018-014-1670-8Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....3e3f768c9bb9ac7ef9a51e6548b42a29 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14209071 1420682X |
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