Robust dengue virus infection in bat cells and limited innate immune responses coupled with positive serology from bats in IndoMalaya and Australasia
| العنوان: | Robust dengue virus infection in bat cells and limited innate immune responses coupled with positive serology from bats in IndoMalaya and Australasia |
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| المؤلفون: | Katarina Luko, Pritisha Rozario, Lin-Fa Wang, H. Benjamin Larman, Benjamin Py H. Lee, Stephen J. Elledge, Ian H. Mendenhall, Shailendra Mani, Jeffrey J. Gorman, Marcus L. Hastie, Pui San Kong, Aaron T. Irving, Gavin J. D. Smith, Wan Ni Chia |
| المصدر: | Cellular and Molecular Life Sciences. 77:1607-1622 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | viruses, Dengue virus, medicine.disease_cause, Virus, Cell Line, Dengue fever, Serology, Dengue, Cellular and Molecular Neuroscience, Immune system, Chiroptera, medicine, Animals, Natural reservoir, Molecular Biology, Pharmacology, Innate immune system, Australasia, biology, Malaysia, Cell Biology, Dengue Virus, Virus Internalization, medicine.disease, biology.organism_classification, Virology, Immunity, Innate, Flavivirus, Host-Pathogen Interactions, Molecular Medicine |
| الوصف: | Natural reservoir hosts can sustain infection of pathogens without succumbing to overt disease. Multiple bat species host a plethora of viruses, pathogenic to other mammals, without clinical symptoms. Here, we detail infection of bat primary cells, immune cells, and cell lines with Dengue virus. While antibodies and viral RNA were previously detected in wild bats, their ability to sustain infection is not conclusive. Old-world fruitbat cells can be infected, producing high titres of virus with limited cellular responses. In addition, there is minimal interferon (IFN) response in cells infected with MOIs leading to dengue production. The ability to support in vitro replication/production raises the possibility of bats as a transient host in the life cycle of dengue or similar flaviviruses. New antibody serology evidence from Asia/Pacific highlights the previous exposure and raises awareness that bats may be involved in flavivirus dynamics and infection of other hosts. |
| تدمد: | 1420-9071 1420-682X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d405a572d5b9dd8a59ef361d76b81dTest https://doi.org/10.1007/s00018-019-03242-xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....29d405a572d5b9dd8a59ef361d76b81d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14209071 1420682X |
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