التفاصيل البيبلوغرافية
| العنوان: |
Long non-coding RNAs are emerging targets of phytochemicals for cancer and other chronic diseases. |
| المؤلفون: |
Mishra, Shruti, Verma, Sumit S., Rai, Vipin, Awasthee, Nikee, Chava, Srinivas, Hui, Kam Man, Kumar, Alan Prem, Challagundla, Kishore B., Sethi, Gautam, Gupta, Subash C. |
| المصدر: |
Cellular & Molecular Life Sciences; May2019, Vol. 76 Issue 10, p1947-1966, 20p, 4 Diagrams, 2 Charts |
| مصطلحات موضوعية: |
NON-coding RNA, CHRONIC diseases, FATTY liver, SMALL molecules, RHEUMATOID arthritis |
| مستخلص: |
The long non-coding RNAs (lncRNAs) are the crucial regulators of human chronic diseases. Therefore, approaches such as antisense oligonucleotides, RNAi technology, and small molecule inhibitors have been used for the therapeutic targeting of lncRNAs. During the last decade, phytochemicals and nutraceuticals have been explored for their potential against lncRNAs. The common lncRNAs known to be modulated by phytochemicals include ROR, PVT1, HOTAIR, MALAT1, H19, MEG3, PCAT29, PANDAR, NEAT1, and GAS5. The phytochemicals such as curcumin, resveratrol, sulforaphane, berberine, EGCG, and gambogic acid have been examined against lncRNAs. In some cases, formulation of phytochemicals has also been used. The disease models where phytochemicals have been demonstrated to modulate lncRNAs expression include cancer, rheumatoid arthritis, osteoarthritis, and nonalcoholic fatty liver disease. The regulation of lncRNAs by phytochemicals can affect multi-steps of tumor development. When administered in combination with the conventional drugs, phytochemicals can also produce synergistic effects on lncRNAs leading to the sensitization of cancer cells. Phytochemicals target lncRNAs either directly or indirectly by affecting a wide variety of upstream molecules. However, the potential of phytochemicals against lncRNAs has been demonstrated mostly by preclinical studies in cancer models. How the modulation of lncRNAs by phytochemicals produce therapeutic effects on cancer and other chronic diseases is discussed in this review. [ABSTRACT FROM AUTHOR] |
|
Copyright of Cellular & Molecular Life Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder