Guillain–Barré syndrome, transverse myelitis and infectious diseases
| العنوان: | Guillain–Barré syndrome, transverse myelitis and infectious diseases |
|---|---|
| المؤلفون: | Diana M. Monsalve, Juan-Manuel Anaya, Yovana Pacheco, Manuel Rojas, Yhojan Rodríguez, Yeny Acosta-Ampudia, Carolina Ramírez-Santana, M. Eric Gershwin |
| المصدر: | Repositorio EdocUR-U. Rosario Universidad del Rosario instacron:Universidad del Rosario |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Cellular immunity, Herpes zoster, Haemophilus infection, Review, Review Article, Communicable diseases, Hepatitis b, Acute motor axonal neuropathy, medicine.disease_cause, Transverse myelitis, Dengue, 0302 clinical medicine, Pathology, Immunology and Allergy, Mycoplasma pneumonia, Innate immunity, Communicable disease, Guillain-Barre syndrome, Myelitis, Cytomegalovirus infection, Host resistance, transverse, Molecular mimicry, Infectious Diseases, Acute inflammatory demyelinating polyneuropathy, Protein antibody, Infection, Human, Herpes simplex, Immunology, Myelitis, Transverse, Nerve fiber membrane, Guillain-Barre Syndrome, Microbiology, Communicable Diseases, 03 medical and health sciences, Disease association, Human immunodeficiency virus infection, Virology, medicine, Humans, Molecular mechanics, Guillain-barre syndrome, business.industry, Immunity, Campylobacter enteritis, Polyradiculoneuropathy, Nonhuman, medicine.disease, Haemophilus influenzae, Humoral immunity, 030104 developmental biology, Zika fever, Guillain barre syndrome, Ganglioside, Chikungunya, business, 030217 neurology & neurosurgery, Hla antigen |
| الوصف: | Guillain–Barré syndrome (GBS) and transverse myelitis (TM) both represent immunologically mediated polyneuropathies of major clinical importance. Both are thought to have a genetic predisposition, but as of yet no specific genetic risk loci have been clearly defined. Both are considered autoimmune, but again the etiologies remain enigmatic. Both may be induced via molecular mimicry, particularly from infectious agents and vaccines, but clearly host factor and co-founding host responses will modulate disease susceptibility and natural history. GBS is an acute inflammatory immune-mediated polyradiculoneuropathy characterized by tingling, progressive weakness, autonomic dysfunction, and pain. Immune injury specifically takes place at the myelin sheath and related Schwann-cell components in acute inflammatory demyelinating polyneuropathy, whereas in acute motor axonal neuropathy membranes on the nerve axon (the axolemma) are the primary target for immune-related injury. Outbreaks of GBS have been reported, most frequently related to Campylobacter jejuni infection, however, other agents such as Zika Virus have been strongly associated. Patients with GBS related to infections frequently produce antibodies against human peripheral nerve gangliosides. In contrast, TM is an inflammatory disorder characterized by acute or subacute motor, sensory, and autonomic spinal cord dysfunction. There is interruption of ascending and descending neuroanatomical pathways on the transverse plane of the spinal cord similar to GBS. It has been suggested to be triggered by infectious agents and molecular mimicry. In this review, we will focus on the putative role of infectious agents as triggering factors of GBS and TM. © 2017, The Chinese Society of Immunology and The University of Science and Technology of China, All rights reserved. |
| وصف الملف: | application/pdf |
| تدمد: | 2042-0226 1672-7681 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f1e65690045802259c4d256e2d96a1Test https://doi.org/10.1038/cmi.2017.142Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....86f1e65690045802259c4d256e2d96a1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20420226 16727681 |
|---|