دورية أكاديمية
The functions and roles of sestrins in regulating human diseases
| العنوان: | The functions and roles of sestrins in regulating human diseases |
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| المؤلفون: | Yitong Chen, Tingben Huang, Zhou Yu, Qiong Yu, Ying Wang, Ji’an Hu, Jiejun Shi, Guoli Yang |
| المصدر: | Cellular & Molecular Biology Letters, Vol 27, Iss 1, Pp 1-24 (2022) |
| بيانات النشر: | BMC, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Cytology |
| مصطلحات موضوعية: | Sestrins, Biological functions, Human diseases, Musculoskeletal system disease, Biomarker, Therapeutic target, Cytology, QH573-671 |
| الوصف: | Abstract Sestrins (Sesns), highly conserved stress-inducible metabolic proteins, are known to protect organisms against various noxious stimuli including DNA damage, oxidative stress, starvation, endoplasmic reticulum (ER) stress, and hypoxia. Sesns regulate metabolism mainly through activation of the key energy sensor AMP-dependent protein kinase (AMPK) and inhibition of mammalian target of rapamycin complex 1 (mTORC1). Sesns also play pivotal roles in autophagy activation and apoptosis inhibition in normal cells, while conversely promoting apoptosis in cancer cells. The functions of Sesns in diseases such as metabolic disorders, neurodegenerative diseases, cardiovascular diseases, and cancer have been broadly investigated in the past decades. However, there is a limited number of reviews that have summarized the functions of Sesns in the pathophysiological processes of human diseases, especially musculoskeletal system diseases. One aim of this review is to discuss the biological functions of Sesns in the pathophysiological process and phenotype of diseases. More significantly, we include some new evidence about the musculoskeletal system. Another purpose is to explore whether Sesns could be potential biomarkers or targets in the future diagnostic and therapeutic process. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1425-8153 1689-1392 |
| العلاقة: | https://doaj.org/toc/1425-8153Test; https://doaj.org/toc/1689-1392Test |
| DOI: | 10.1186/s11658-021-00302-8 |
| الوصول الحر: | https://doaj.org/article/e5d48cd8363a42e49c629b5312d3549aTest |
| رقم الانضمام: | edsdoj.5d48cd8363a42e49c629b5312d3549a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14258153 16891392 |
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| DOI: | 10.1186/s11658-021-00302-8 |