Generation of Human Stomach Cancer iPSC-Derived Organoids Induced by Helicobacter pylori Infection and Their Application to Gastric Cancer Research
| العنوان: | Generation of Human Stomach Cancer iPSC-Derived Organoids Induced by Helicobacter pylori Infection and Their Application to Gastric Cancer Research |
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| المؤلفون: | Chia-Chen Ku, Kenly Wuputra, Jia-Bin Pan, Chia-Pei Li, Chung-Jung Liu, Yi-Chang Liu, Shigeo Saito, Te-Fu Chan, Chang-Shen Lin, Deng-Chyang Wu, Kazunari K. Yokoyama |
| المصدر: | Cells, Vol 11, Iss 184, p 184 (2022) Cells |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Biomedical Research, Helicobacter pylori, QH301-705.5, Induced Pluripotent Stem Cells, Review, General Medicine, Helicobacter Infections, Tissue Culture Techniques, Stomach Neoplasms, Humans, stomach corpus stem cells, Biology (General), stomach antral stem cells, stem cell niches, organoids |
| الوصف: | There is considerable cellular diversity in the human stomach, which has helped to clarify cell plasticity in normal development and tumorigenesis. Thus, the stomach is an interesting model for understanding cellular plasticity and for developing prospective anticancer therapeutic agents. However, many questions remain regarding the development of cancers in vivo and in vitro in two- or three-dimensional (2D/3D) cultures, as well as the role of Helicobacter pylori (H. p.) infection. Here, we focus on the characteristics of cancer stem cells and their derived 3D organoids in culture, including the formation of stem cell niches. We define the conditions required for such organoid culture in vitro and examine the ability of such models for testing the use of anticancer agents. We also summarize the signaling cascades and the specific markers of stomach-cancer-derived organoids induced by H. p. infection, and their stem cell niches. |
| اللغة: | English |
| تدمد: | 2073-4409 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e429516c4dd6d96be4f945b9c91901c1Test https://www.mdpi.com/2073-4409/11/2/184Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e429516c4dd6d96be4f945b9c91901c1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734409 |
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