Deciphering Nuclear Mechanobiology in Laminopathy
| العنوان: | Deciphering Nuclear Mechanobiology in Laminopathy |
|---|---|
| المؤلفون: | Jungwon Hah, Dong Hwee Kim |
| المصدر: | Cells, Vol 8, Iss 3, p 231 (2019) Cells |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Cellular homeostasis, Context (language use), Laminopathy, Review, laminopathy, Biology, Mechanotransduction, Cellular, Models, Biological, Biophysical Phenomena, 03 medical and health sciences, Mechanobiology, 0302 clinical medicine, medicine, Animals, Humans, Inner membrane, lamin, Mechanotransduction, lcsh:QH301-705.5, Nuclear Lamina, nucleus, cytoskeleton, General Medicine, medicine.disease, Lamins, Cell biology, 030104 developmental biology, lcsh:Biology (General), Nuclear lamina, 030217 neurology & neurosurgery, Lamin |
| الوصف: | Extracellular mechanical stimuli are translated into biochemical signals inside the cell via mechanotransduction. The nucleus plays a critical role in mechanoregulation, which encompasses mechanosensing and mechanotransduction. The nuclear lamina underlying the inner nuclear membrane not only maintains the structural integrity, but also connects the cytoskeleton to the nuclear envelope. Lamin mutations, therefore, dysregulate the nuclear response, resulting in abnormal mechanoregulations, and ultimately, disease progression. Impaired mechanoregulations even induce malfunction in nuclear positioning, cell migration, mechanosensation, as well as differentiation. To know how to overcome laminopathies, we need to understand the mechanisms of laminopathies in a mechanobiological way. Recently, emerging studies have demonstrated the varying defects from lamin mutation in cellular homeostasis within mechanical surroundings. Therefore, this review summarizes recent findings highlighting the role of lamins, the architecture of nuclear lamina, and their disease relevance in the context of nuclear mechanobiology. We will also provide an overview of the differentiation of cellular mechanics in laminopathy. |
| اللغة: | English |
| تدمد: | 2073-4409 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc31b1bc7f6d45adf00c4da35a507a2Test http://www.mdpi.com/2073-4409/8/3/231Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8bc31b1bc7f6d45adf00c4da35a507a2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734409 |
|---|