Indoleamine 2, 3-dioxygenase (IDO) is essential for dendritic cell activation and chemotactic responsiveness to chemokines
| العنوان: | Indoleamine 2, 3-dioxygenase (IDO) is essential for dendritic cell activation and chemotactic responsiveness to chemokines |
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| المؤلفون: | Chen-Lung Steve Lin, Nancy P. Y. Chung, Shih Ling Hwang, Jacqueline K. Y. Chan |
| المصدر: | Cell Research. 15:167-175 |
| بيانات النشر: | Springer Science and Business Media LLC, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Lipopolysaccharides, Receptors, CXCR5, Receptors, CXCR4, Chemokine, T-Lymphocytes, medicine.medical_treatment, T cell, Biology, medicine, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, CD40 Antigens, Receptors, Cytokine, Indoleamine 2,3-dioxygenase, Molecular Biology, Cells, Cultured, Cell Proliferation, CD40, Tumor Necrosis Factor-alpha, Cell growth, Chemotaxis, Tryptophan, Dendritic Cells, Cell Biology, Dendritic cell, Cell biology, Cytokine, medicine.anatomical_structure, Immunology, biology.protein, Receptors, Chemokine, Chemokines |
| الوصف: | Indoleamine 2, 3-dioxygenase (IDO) is a rate-limiting enzyme for the tryptophan catabolism. In human and murine cells, IDO inhibits antigen-specific T cell proliferation in vitro and suppresses T cell responses to fetal alloantigens during murine pregnancy. In mice, IDO expression is an inducible feature of specific subsets of dendritic cells (DCs), and is important for T cell regulatory properties. However, the effect of IDO and tryptophan deprivation on DC functions remains unknown. We report here that when tryptophan utilization was prevented by a pharmacological inhibitor of IDO, 1-methyl tryptophan (1MT), DC activation induced by pathogenic stimulus lipopolysaccharide (LPS) or inflammatory cytokine TNF-alpha was inhibited both phenotypically and functionally. Such an effect was less remarkable when DC was stimulated by a physiological stimulus, CD40 ligand. Tryptophan deprivation during DC activation also regulated the expression of CCR5 and CXCR4, as well as DC responsiveness to chemokines. These results suggest that tryptophan usage in the microenvironment is essential for DC maturation, and may also play a role in the regulation of DC migratory behaviors. |
| تدمد: | 1748-7838 1001-0602 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a9d2cae8f196ef59bac3fa191d6a15Test https://doi.org/10.1038/sj.cr.7290282Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....93a9d2cae8f196ef59bac3fa191d6a15 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17487838 10010602 |
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