A distinct innate immune signature marks progression from mild to severe COVID-19
| العنوان: | A distinct innate immune signature marks progression from mild to severe COVID-19 |
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| المؤلفون: | Yves Zurbuchen, Andrea Jacobs, Lars C. Huber, Esther B. Bachli, Dominik J. Schaer, Sujana Sivapatham, Alain Rudiger, Bernd Bodenmiller, Melina Stüssi-Helbling, Natalie de Souza, Stéphane Chevrier, Sarah Adamo, Miro E. Raeber, Jakob Nilsson, Onur Boyman, Carlo Cervia |
| المساهمون: | University of Zurich, Nilsson, Jakob, Boyman, Onur, Bodenmiller, Bernd |
| المصدر: | Cell Reports Medicine Cell Reports Medicine, 2 (1) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Proteomics, mass cytometry, Sialic Acid Binding Ig-like Lectin 1, CCL3, Inflammation, 2700 General Medicine, macromolecular substances, CD16, Sars-Cov-2, COVID-19, Innate immune response, Mass cytometry, Monocytes, emergency granulopoiesis, sialoadhesin, CD169, MIP1α, Severity of Illness Index, General Biochemistry, Genetics and Molecular Biology, Mass Spectrometry, Article, Immune system, 1300 General Biochemistry, Genetics and Molecular Biology, Sialoadhesin, Medicine, Humans, Myeloid Cells, Innate immune system, business.industry, SARS-CoV-2, Middle Aged, Phenotype, 10124 Institute of Molecular Life Sciences, Immunity, Innate, C-Reactive Protein, inflammation, Immunology, 10033 Clinic for Immunology, innate immune response, 570 Life sciences, biology, Cytokines, Female, 10029 Clinic and Policlinic for Internal Medicine, medicine.symptom, business, 11493 Department of Quantitative Biomedicine |
| الوصف: | Summary Coronavirus disease 2019 (COVID-19) manifests with a range of severities, but immune signatures of mild and severe disease are still not fully understood. Here, we use mass cytometry and targeted proteomics to profile the innate immune response of patients with mild or severe COVID-19 and of healthy individuals. Sampling at different stages allows us to reconstruct a pseudo-temporal trajectory of the innate response. A surge of CD169+ monocytes associated with an IFN-γ+MCP-2+ signature rapidly follows symptom onset. At later stages, we observe a persistent inflammatory phenotype in patients with severe disease, dominated by high CCL3 and CCL4 abundance correlating with the re-appearance of CD16+ monocytes, whereas the response of mild COVID-19 patients normalizes. Our data provide insights into the dynamic nature of inflammatory responses in COVID-19 patients and identify sustained innate immune responses as a likely mechanism in severe patients, thus supporting the investigation of targeted interventions in severe COVID-19. Graphical Abstract Highlights Systems analysis of the innate immune responses in COVID-19 up to 47 days after onset Surge of CD169+ and depletion of CD16+CD14− monocytes early after symptom onset High levels of inflammatory cytokines and immature neutrophils in severe COVID-19 Persistent inflammation in late severe cases, while normalization in mild cases Chevrier et al. characterize the innate immune response in mild and severe COVID-19 patients and healthy individuals by mass cytometry and serum proteomics. They demonstrate profound phenotypic changes after SARS-CoV-2 infection and ongoing inflammation, with an innate signature switch in severe COVID-19 patients late in the disease course. |
| وصف الملف: | application/application/pdf; ZORA198565.pdf - application/pdf |
| تدمد: | 2666-3791 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2385aa4a5c67b42d569d27898a1bd6Test https://pubmed.ncbi.nlm.nih.gov/33521697Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ed2385aa4a5c67b42d569d27898a1bd6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26663791 |
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