Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome
| العنوان: | Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome |
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| المؤلفون: | Risal, Sanjiv, Li, Congru, Luo, Qing, Fornes, Romina, Lu, Haojiang, Eriksson, Gustaw, Manti, Maria, Ohlsson, Claes, Lindgren, Eva, Crisosto, Nicolas, Maliqueo, Manuel, Echiburú, Barbara, Recabarren, Sergio, Petermann, Teresa Sir, Benrick, Anna, 1979, Brusselaers, Nele, Qiao, Jie, Deng, Qiaolin, Stener-Victorin, Elisabet |
| المصدر: | Cell Reports Medicine. 4(5) |
| مصطلحات موضوعية: | adipose tissue, male offspring, male offspring to male germline, maternal hyperandrogenism, maternal obesity, polycystic ovary syndrome, small non-coding RNAs, sperm, transgenerational transmission, Animals, Case-Control Studies, Female, Humans, Male, Mice, Obesity, Pregnancy, Reproduction, Semen, small untranslated RNA, animal experiment, animal model, animal tissue, Article, case control study, childhood obesity, cohort analysis, controlled study, differential gene expression, dyslipidemia, fetus outcome, fetus risk, gene locus, genetic risk, genital system disease, germ line, high risk infant, high risk patient, human, hyperandrogenism, maternal fetal transmission, metabolic disorder, mouse, nonhuman, ovary polycystic disease, prenatal exposure, progeny, risk assessment, RNA analysis, vertical transmission, animal, genetics, Translationell medicin TRIM, Translational Medicine TRIM |
| الوصف: | The transgenerational maternal effects of polycystic ovary syndrome (PCOS) in female progeny are being revealed. As there is evidence that a male equivalent of PCOS may exists, we ask whether sons born to mothers with PCOS (PCOS-sons) transmit reproductive and metabolic phenotypes to their male progeny. Here, in a register-based cohort and a clinical case-control study, we find that PCOS-sons are more often obese and dyslipidemic. Our prenatal androgenized PCOS-like mouse model with or without diet-induced obesity confirmed that reproductive and metabolic dysfunctions in first-generation (F1) male offspring are passed down to F3. Sequencing of F1–F3 sperm reveals distinct differentially expressed (DE) small non-coding RNAs (sncRNAs) across generations in each lineage. Notably, common targets between transgenerational DEsncRNAs in mouse sperm and in PCOS-sons serum indicate similar effects of maternal hyperandrogenism, strengthening the translational relevance and highlighting a previously underappreciated risk of transmission of reproductive and metabolic dysfunction via the male germline. |
| وصف الملف: | electronic |
| الوصول الحر: | https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-22630Test https://doi.org/10.1016/j.xcrm.2023.101035Test https://his.diva-portal.org/smash/get/diva2:1761313/FULLTEXT01.pdfTest |
| قاعدة البيانات: | SwePub |
| DOI: | 10.1016/j.xcrm.2023.101035 |
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