التفاصيل البيبلوغرافية
| العنوان: |
Neural assemblies coordinated by cortical waves are associated with waking and hallucinatory brain states. |
| المؤلفون: |
Aggarwal, Adeeti, Luo, Jennifer, Chung, Helen, Contreras, Diego, Kelz, Max B., Proekt, Alex |
| المصدر: |
Cell Reports; Apr2024, Vol. 43 Issue 4, pN.PAG-N.PAG, 1p |
| مستخلص: |
The relationship between sensory stimuli and perceptions is brain-state dependent: in wakefulness, suprathreshold stimuli evoke perceptions; under anesthesia, perceptions are abolished; and during dreaming and in dissociated states, percepts are internally generated. Here, we exploit this state dependence to identify brain activity associated with internally generated or stimulus-evoked perceptions. In awake mice, visual stimuli phase reset spontaneous cortical waves to elicit 3–6 Hz feedback traveling waves. These stimulus-evoked waves traverse the cortex and entrain visual and parietal neurons. Under anesthesia as well as during ketamine-induced dissociation, visual stimuli do not disrupt spontaneous waves. Uniquely, in the dissociated state, spontaneous waves traverse the cortex caudally and entrain visual and parietal neurons, akin to stimulus-evoked waves in wakefulness. Thus, coordinated neuronal assemblies orchestrated by traveling cortical waves emerge in states in which perception can manifest. The awake state is privileged in that this coordination is reliably elicited by external visual stimuli. [Display omitted] • In wakefulness, visual stimuli reliably elicit feedback traveling cortical waves • Stimulus-evoked traveling waves coordinate firing of individual neurons across the cortex • Under anesthesia and in dissociative states, stimuli do not disrupt spontaneous waves • In dissociative states, spontaneous activity resembles stimulus-evoked waves in wakefulness During wakefulness, visual stimuli elicit perceptual experiences, while under the influence of hallucinogens, perceptual experiences unrelated to stimuli arise spontaneously. Aggarwal et al. show that in awake mice, visual stimuli elicit cortical traveling waves. Under ketamine—a potent hallucinogen—similar cortical waves arise spontaneously and are unaffected by stimuli. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
