Neuromedin U Does Not Act as a Decretin in Rats
| العنوان: | Neuromedin U Does Not Act as a Decretin in Rats |
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| المؤلفون: | Mette M. Rosenkilde, Thomas Mandrup-Poulsen, C. Christiansen, Bolette Hartmann, Seyed Mojtaba Ghiasi, Ida M. Modvig, Jens J. Holst, Patricia Almine Skat-Rørdam, Rune E. Kuhre, Maria Buur Nordskov Gabe, Nicolai J. Wewer Albrechtsen, Reidar Albrechtsen |
| المصدر: | Kuhre, R E, Christiansen, C B, Ghiasi, S M, Gabe, M B N, Skat-Rørdam, P A, Modvig, I M, Mandrup-Poulsen, T, Albrechtsen, R, Rosenkilde, M M, Hartmann, B, Albrechtsen, N J W & Holst, J J 2019, ' Neuromedin U Does Not Act as a Decretin in Rats ', Cell Metabolism, vol. 29, no. 3, pp. 719-726.e1-e5 . https://doi.org/10.1016/j.cmet.2018.10.008Test Cell Metabolism |
| بيانات النشر: | Elsevier BV, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, insulin secretion, endocrine system, medicine.medical_specialty, Physiology, Somatostatin secretion, medicine.medical_treatment, Glucagon, Islets of Langerhans, 03 medical and health sciences, 0302 clinical medicine, neuromedin U, Internal medicine, Chlorocebus aethiops, Intestine, Small, medicine, Animals, Humans, Insulin, Rats, Wistar, Receptor, Pancreas, Molecular Biology, Chemistry, Pancreatic islets, Neuropeptides, digestive, oral, and skin physiology, Cell Biology, decretin, neuromedin U receptor 1 and 2, Glucagon-like peptide-1, glucagon-like peptide 1, Rats, Receptors, Neurotransmitter, 3. Good health, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, COS Cells, type 2 diabetes, Somatostatin, hormones, hormone substitutes, and hormone antagonists, 030217 neurology & neurosurgery, Neuromedin U, Hormone |
| الوصف: | Summary Studies on isolated pancreatic islets suggest that neuromedin U (NMU), a brain and gastrointestinal peptide, acts as a decretin hormone, inhibiting glucose-stimulated insulin secretion. We investigated whether this effect could be reproduced in vivo and in isolated perfused rat pancreas. Unlike the incretin hormone, glucagon-like peptide 1 (GLP-1), intravenous NMU administration had no effects on blood glucose and plasma insulin and glucagon in vivo. Moreover, NMU neither changed insulin, glucagon, or somatostatin secretion from isolated perfused rat pancreas, nor affected GLP-1-stimulated insulin and somatostatin secretion. For NMU to act as a decretin hormone, its secretion should increase following glucose ingestion; however, glucose did not affect NMU secretion from isolated perfused rat small intestine, which contained extractable NMU. Furthermore, the two NMU receptors were not detected in endocrine rat or human pancreas. We conclude that NMU does not act as a decretin hormone in rats. |
| وصف الملف: | application/pdf |
| تدمد: | 1550-4131 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b410c676abf556b2b5937bd4e51d006dTest https://doi.org/10.1016/j.cmet.2018.10.008Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b410c676abf556b2b5937bd4e51d006d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15504131 |
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