Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction
| العنوان: | Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction |
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| المؤلفون: | Cara L. Green, Heidi H. Pak, Nicole E. Richardson, Victoria Flores, Deyang Yu, Jay L. Tomasiewicz, Sabrina N. Dumas, Katherine Kredell, Jesse W. Fan, Charlie Kirsh, Krittisak Chaiyakul, Michaela E. Murphy, Reji Babygirija, Gregory A. Barrett-Wilt, Joshua Rabinowitz, Irene M. Ong, Cholsoon Jang, Judith Simcox, Dudley W. Lamming |
| المصدر: | Cell Metab Cell metabolism, vol 34, iss 2 |
| بيانات النشر: | Elsevier BV, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Male, precision dietetics, Physiology, 1.1 Normal biological development and functioning, Protein-Restricted, Medical Biochemistry and Metabolomics, UM-HET3, liver, Article, Endocrinology & Metabolism, Mice, FGF21, Underpinning research, Genetics, Diet, Protein-Restricted, 2.2 Factors relating to the physical environment, Animals, protein restriction, Obesity, Aetiology, Molecular Biology, Metabolic and endocrine, Nutrition, metabolic health, Prevention, Diabetes, Cell Biology, multi-omics, Diet, Fibroblast Growth Factors, Good Health and Well Being, Liver, sexual dimorphism, genetic variation, Female, Biochemistry and Cell Biology, Insulin Resistance, Energy Metabolism, Genetic Background |
| الوصف: | Low-protein diets promote metabolic health in humans and rodents. Despite evidence that sex and genetic background are key factors in the response to diet, most protein intake studies examine only a single strain and sex of mice. Using multiple strains and both sexes of mice, we find that improvements in metabolic health in response to reduced dietary protein strongly depend on sex and strain. While some phenotypes were conserved across strains and sexes, including increased glucose tolerance and energy expenditure, we observed high variability in adiposity, insulin sensitivity, and circulating hormones. Using a multi-omics approach, we identified mega-clusters of differentially expressed hepatic genes, metabolites, and lipids associated with each phenotype, providing molecular insight into the differential response to protein restriction. Our results highlight the importance of sex and genetic background in the response to dietary protein level, and the potential importance of a personalized medicine approach to dietary interventions. |
| وصف الملف: | application/pdf |
| تدمد: | 1550-4131 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825d32fca3c4b749e001a577305661ebTest https://doi.org/10.1016/j.cmet.2021.12.018Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....825d32fca3c4b749e001a577305661eb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15504131 |
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