Mitofusin 2: from functions to disease
| العنوان: | Mitofusin 2: from functions to disease |
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| المؤلفون: | Riccardo Filadi, Diana Pendin, Paola Pizzo |
| المصدر: | Cell Death and Disease, Vol 9, Iss 3, Pp 1-13 (2018) Cell Death & Disease |
| بيانات النشر: | Nature Publishing Group, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Bioenergetics, Immunology, Cell, Mitochondrion, Biology, GTP Phosphohydrolases, Mitochondrial Proteins, 03 medical and health sciences, Cellular and Molecular Neuroscience, Mitofusin-2, Metabolic Diseases, Neoplasms, Organelle, medicine, Animals, Humans, Viability assay, lcsh:QH573-671, Review Paper, lcsh:Cytology, Endoplasmic reticulum, Neurodegenerative Diseases, Cell Biology, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Cardiomyopathies, Function (biology) |
| الوصف: | Mitochondria are highly dynamic organelles whose functions are essential for cell viability. Within the cell, the mitochondrial network is continuously remodeled through the balance between fusion and fission events. Moreover, it dynamically contacts other organelles, particularly the endoplasmic reticulum, with which it enterprises an important functional relationship able to modulate several cellular pathways. Being mitochondria key bioenergetics organelles, they have to be transported to all the specific high-energy demanding sites within the cell and, when damaged, they have to be efficiently removed. Among other proteins, Mitofusin 2 represents a key player in all these mitochondrial activities (fusion, trafficking, turnover, contacts with other organelles), the balance of which results in the appropriate mitochondrial shape, function, and distribution within the cell. Here we review the structural and functional properties of Mitofusin 2, highlighting its crucial role in several cell pathways, as well as in the pathogenesis of neurodegenerative diseases, metabolic disorders, cardiomyopathies, and cancer. |
| اللغة: | English |
| تدمد: | 2041-4889 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745a5914ce0fdc06f10bcdb84f2225b2Test http://link.springer.com/article/10.1038/s41419-017-0023-6Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....745a5914ce0fdc06f10bcdb84f2225b2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20414889 |
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