LDHA induces EMT gene transcription and regulates autophagy to promote the metastasis and tumorigenesis of papillary thyroid carcinoma
| العنوان: | LDHA induces EMT gene transcription and regulates autophagy to promote the metastasis and tumorigenesis of papillary thyroid carcinoma |
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| المؤلفون: | Xianhui Ruan, Xiangqian Zheng, Dapeng Li, Ming Gao, Wei Zhang, Jingzhu Zhao, Xiukun Hou, Linfei Hu, Songfeng Wei, Xianle Shi, Jihong Yang, Xi Wei |
| المصدر: | Cell Death and Disease, Vol 12, Iss 4, Pp 1-18 (2021) Cell Death & Disease |
| بيانات النشر: | Nature Publishing Group, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cancer Research, Epithelial-Mesenchymal Transition, endocrine system diseases, Carcinogenesis, Lactate dehydrogenase A, Immunology, Cell, Biology, medicine.disease_cause, Article, Thyroid cancer, Metastasis, Target validation, Cellular and Molecular Neuroscience, Cell Movement, medicine, Autophagy, Humans, Thyroid Neoplasms, Neoplasm Metastasis, lcsh:QH573-671, education, Cell Proliferation, Gene knockdown, education.field_of_study, lcsh:Cytology, Cancer, Cell Biology, medicine.disease, Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, Cell Transformation, Neoplastic, Thyroid Cancer, Papillary, Cancer research, Lactate Dehydrogenase 5 |
| الوصف: | Papillary thyroid carcinoma (PTC) is one of the most common kinds of endocrine-related cancer and has a heterogeneous prognosis. Metabolic reprogramming is one of the hallmarks of cancers. Aberrant glucose metabolism is associated with malignant biological behavior. However, the functions and mechanisms of glucose metabolism genes in PTC are not fully understood. Thus, data from The Cancer Genome Atlas database were analyzed, and lactate dehydrogenase A (LDHA) was determined to be a potential novel diagnostic and therapeutic target for PTCs. The research objective was to investigate the expression of LDHA in PTCs and to explore the main functions and relative mechanisms of LDHA in PTCs. Higher expression levels of LDHA were found in PTC tissues than in normal thyroid tissues at both the mRNA and protein levels. Higher expression levels of LDHA were correlated with aggressive clinicopathological features and poor prognosis. Moreover, we found that LDHA not only promoted PTC migration and invasion but also enhanced tumor growth both in vitro and in vivo. In addition, we revealed that the metabolic products of LDHA catalyzed induced the epithelial–mesenchymal transition process by increasing the relative gene H3K27 acetylation. Moreover, LDHA knockdown activated the AMPK pathway and induced protective autophagy. An autophagy inhibitor significantly enhanced the antitumor effect of FX11. These results suggested that LDHA enhanced the cell metastasis and proliferation of PTCs and may therefore become a potential therapeutic target for PTCs. |
| اللغة: | English |
| تدمد: | 2041-4889 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6657bad5ae3a3656ba45fa3b8721feTest https://doaj.org/article/408a7957434547a6892ba9f593efb0d2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ad6657bad5ae3a3656ba45fa3b8721fe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20414889 |
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