Correction: ATRIP protects progenitor cells against DNA damage in vivo
| العنوان: | Correction: ATRIP protects progenitor cells against DNA damage in vivo |
|---|---|
| المؤلفون: | Rodrigo A. P. Martins, Pierre Olivier Frappart, Gabriel E. Matos-Rodrigues, Paulius Grigaravicius, Bernard S. Lopez, Thomas G. Hofmann |
| المصدر: | Cell Death & Disease Cell Death and Disease, Vol 11, Iss 12, Pp 1-1 (2020) |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Checkpoints, DNA Replication, Cancer Research, lcsh:Cytology, Disease model, DNA damage, Chemistry, Stem Cells, Immunology, Correction, Cell Biology, DNA damage response, Cell biology, DNA-Binding Proteins, Mice, Cellular and Molecular Neuroscience, In vivo, Animals, Humans, lcsh:QH573-671, Progenitor cell, Cell proliferation, Adaptor Proteins, Signal Transducing, DNA Damage |
| الوصف: | The maintenance of genomic stability during the cell cycle of progenitor cells is essential for the faithful transmission of genetic information. Mutations in genes that ensure genome stability lead to human developmental syndromes. Mutations in Ataxia Telangiectasia and Rad3-related (ATR) or in ATR-interacting protein (ATRIP) lead to Seckel syndrome, which is characterized by developmental malformations and short life expectancy. While the roles of ATR in replicative stress response and chromosomal segregation are well established, it is unknown how ATRIP contributes to maintaining genomic stability in progenitor cells in vivo. Here, we generated the first mouse model to investigate ATRIP function. Conditional inactivation of Atrip in progenitor cells of the CNS and eye led to microcephaly, microphthalmia and postnatal lethality. To understand the mechanisms underlying these malformations, we used lens progenitor cells as a model and found that ATRIP loss promotes replicative stress and TP53-dependent cell death. Trp53 inactivation in Atrip-deficient progenitor cells rescued apoptosis, but increased mitotic DNA damage and mitotic defects. Our findings demonstrate an essential role of ATRIP in preventing DNA damage accumulation during unchallenged replication. |
| تدمد: | 2041-4889 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850df5af51d4d3d1231cc11ab59158bdTest https://doi.org/10.1038/s41419-020-03227-wTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....850df5af51d4d3d1231cc11ab59158bd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20414889 |
|---|