التفاصيل البيبلوغرافية
| العنوان: |
Different apoptotic mechanisms are involved in the antiproliferative effects of 7ß-hydroxysitosterol and 7ß-hydroxycholesterol in human colon cancer cells. |
| المؤلفون: |
Roussi, S., Winter, A., Gosse, F., Werner, D., Zhang, X., Marchioni, E., Geoffroy, P., Miesch, M., Raul, F. |
| المصدر: |
Cell Death & Differentiation; Feb2005, Vol. 12 Issue 2, p128-135, 8p |
| مصطلحات موضوعية: |
APOPTOSIS, STEROLS, COLON cancer, CANCER cells, CELL lines, DNA |
| مستخلص: |
Plant sterols are found in fruits and vegetables. Their cholesterol-lowering effect is well documented. Our study aimed at comparing antiproliferative effects of 7ß-hydroxysitosterol (7ß-OHsito) versus 7ß-hydroxycholesterol (7ß-OHchol) on the human colon cancer cell line Caco-2. When cells were exposed for 32?h to 60?µM 7ß-OHsito or to 30?µM 7ß-OHchol, both compounds caused 50%growth inhibition. Cells treated with 7ß-OHsito showed enhanced caspase-9 and -3 activities followed by DNA fragmentation. In contrast, 7ß-OHchol did not activate caspase-3 and activation of caspase-9 and DNA fragmentation were delayed. The treatment of cells with the caspase inhibitor Z-VAD.fmk retarded the 7ß-OHsito-induced apoptotic process but not that triggered by 7ß-OHchol. Our data suggest that the two compounds in spite of their structural similarities target different cellular pathways, which lead to cell death.Cell Death and Differentiation (2005) 12, 128-135. doi:10.1038/sj.cdd.4401530 Published online 19 November 2004 [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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