Escape from p53-mediated tumor surveillance in neuroblastoma: switching off the p14ARF-MDM2-p53 axis
| العنوان: | Escape from p53-mediated tumor surveillance in neuroblastoma: switching off the p14ARF-MDM2-p53 axis |
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| المؤلفون: | A. De Paepe, T. Van Maerken, J Vandesompele, Franki Speleman, Ali Rihani |
| المصدر: | Cell Death & Differentiation. 16:1563-1572 |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Cancer, Proto-Oncogene Proteins c-mdm2, Growth control, Cell Biology, Biology, medicine.disease_cause, medicine.disease, Gene Expression Regulation, Neoplastic, Neuroblastoma, p14arf, Tumor Suppressor Protein p14ARF, medicine, Cancer research, biology.protein, Animals, Humans, Mdm2, Mdm2 p53, Tumor Suppressor Protein p53, Carcinogenesis, Molecular Biology, Gene, Signal Transduction |
| الوصف: | A primary failsafe program against unrestrained proliferation and oncogenesis is provided by the p53 tumor suppressor protein, inactivation of which is considered as a hallmark of cancer. Intriguingly, mutations of the TP53 gene are rarely encountered in neuroblastoma tumors, suggesting that alternative p53-inactivating lesions account for escape from p53 control in this childhood malignancy. Several recent studies have shed light on the mechanisms by which neuroblastoma cells circumvent the p53-driven antitumor barrier. We review here these mechanisms for evasion of p53-mediated growth control and conclude that deregulation of the p14(ARF)-MDM2-p53 axis seems to be the principal mode of p53 inactivation in neuroblastoma, opening new perspectives for targeted therapeutic intervention. |
| تدمد: | 1476-5403 1350-9047 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d7e541f133269c8b4b20c67f383371Test https://doi.org/10.1038/cdd.2009.138Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e1d7e541f133269c8b4b20c67f383371 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765403 13509047 |
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