Oncogenic K-ras in Mouse Models of Myeloproliferative Disease and Acute Myeloid Leukemia
| العنوان: | Oncogenic K-ras in Mouse Models of Myeloproliferative Disease and Acute Myeloid Leukemia |
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| المؤلفون: | Iris T. Chan, D. Gary Gilliland |
| المصدر: | Cell Cycle. 3:534-535 |
| بيانات النشر: | Informa UK Limited, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Regulation of gene expression, medicine.drug_class, Histone deacetylase inhibitor, Promoter, Cell Biology, Biology, Virology, Chromatin, Histone, Cell culture, Gene expression, medicine, Cancer research, biology.protein, Molecular Biology, Vorinostat, Developmental Biology, medicine.drug |
| الوصف: | Histone deacetylases (HDAC) are ubiquitously distributed through chromatin. Nevertheless HDAC inhibitors (HDACi), such as SAHA, selectively alter the transcription of as few as 2-5% of expressed genes in various transformed cells. p21(WAF1) is one of the most commonly induced genes in cells cultured with SAHA. Understanding the mechanism of the selective effects of the HDACi is a challenging problem. Gui et al. have identified effects of SAHA on p21(WAF1) promotor associated proteins that explain, at least in part, the selective effects of HDAC in altering gene expression. |
| تدمد: | 1551-4005 1538-4101 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::36cdefac349c9183b65f4a5b159319c0Test https://doi.org/10.4161/cc.3.5.827Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........36cdefac349c9183b65f4a5b159319c0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15514005 15384101 |
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