Conflicting Roles for p63 in Skin Development and Carcinogenesis
| العنوان: | Conflicting Roles for p63 in Skin Development and Carcinogenesis |
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| المؤلفون: | Daisy Dai, Maranke I. Koster, Dennis R. Roop |
| المصدر: | Cell Cycle. 6:269-273 |
| بيانات النشر: | Informa UK Limited, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Morphogenesis, Biology, medicine.disease_cause, Models, Biological, medicine, Animals, Humans, Molecular Biology, Transcription factor, Organism, Skin, integumentary system, Epidermis (botany), Tumor Suppressor Proteins, Cell Biology, Phenotype, Cell biology, DNA-Binding Proteins, stomatognathic diseases, Cell Transformation, Neoplastic, medicine.anatomical_structure, Mutation, Trans-Activators, sense organs, Epidermis, Epidermal morphogenesis, Keratinocyte, Carcinogenesis, Signal Transduction, Transcription Factors, Developmental Biology |
| الوصف: | Epidermal morphogenesis is a complex process that culminates in the formation of a barrier that protects the organism from environmental substances and dehydration. p63, a transcription factor, is essential for normal epidermal morphogenesis as demonstrated by the failure of mice lacking p63 expression to develop an epidermis. However, since two independently generated p63(-/-) mouse models displayed different phenotypes, the role of p63 in epidermal morphogenesis has remained controversial. Furthermore, the tumor susceptibility phenotypes of both p63(-/-) mouse models were strikingly different. In this review, we discuss these conflicting findings and provide evidence for various roles of p63 in the epidermis under normal and pathological conditions. |
| تدمد: | 1551-4005 1538-4101 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa122ada6d0947e956d429e3d3154a7Test https://doi.org/10.4161/cc.6.3.3792Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9aa122ada6d0947e956d429e3d3154a7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15514005 15384101 |
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