التفاصيل البيبلوغرافية
| العنوان: |
Evidence that macrophages transfer arachidonic acid and cholesterol to tissues in vivo. |
| المؤلفون: |
C. M. Peres, P. I. Homem de Bittencourt, J. R. Mendonça, R. Curi |
| المصدر: |
Cell Biochemistry & Function; Dec2003, Vol. 21 Issue 4, p317-323, 7p |
| مصطلحات موضوعية: |
CHOLESTEROL, ARACHIDONIC acid, MACROPHAGES, LYMPHOCYTES, CELLS, LIPIDS |
| مستخلص: |
Our previous studies have shown that [14C]-labelled cholesterol (CHOL) and arachidonic acid (AA) are transferred from macrophages (Mϕ) to lymphocytes (LY) when these cells are co-cultured. In this study, we investigated whether these lipids can be transferred from control and thioglycollate-elicited Mϕ (THIO-elicited Mϕ) to various tissues and organs in vivo. For this purpose, control and THIO-elicited Mϕ were pre-treated with [14C]-AA and [3H]-CHOL and then injected into the jugular vein of adult rats. More than 75% of the radioactivity injected was found in the liver of rats treated with [14C]-AA labelled-Mϕ either control and THIO-stimulated. The radioactivity of [3H]-CHOL labelled Mϕ was transferred mainly to the liver (51% in the control Mϕ and 23% in the thioglycollate Mϕ7) but it was also found in the kidney, lung and spleen. These results support the proposition that the transfer of lipids between cells also occurs in vivo. The full significance of this phenomenon however remains to be elucidated. Copyright © 2003 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
