Collagens and proteoglycans of the cornea: importance in transparency and visual disorders
| العنوان: | Collagens and proteoglycans of the cornea: importance in transparency and visual disorders |
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| المؤلفون: | François Malecaze, Stéphane Galiacy, Dawiyat Massoudi |
| المساهمون: | Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse] |
| المصدر: | Cell and Tissue Research Cell and Tissue Research, Springer Verlag, 2016, 363 (2), pp.337-349. ⟨10.1007/s00441-015-2233-5⟩ |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | 0301 basic medicine, Corneal opacities, Histology, genetic structures, Vision Disorders, Models, Biological, FACIT, Pathology and Forensic Medicine, Cornea, MESH: Vision Disorders / metabolism, Extracellular matrix, 03 medical and health sciences, Stroma, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, MESH: Collagen / metabolism, medicine, Animals, Humans, MESH: Animals, MESH: Cornea / physiopathology, Wound Healing, MESH: Humans, Chemistry, Corneal transparency, MESH: Models, Biological, Cell Biology, Anatomy, MESH: Cornea / pathology, eye diseases, Type V collagen, Epithelium, MESH: Cornea / metabolism, Cell biology, SLRPs, MESH: Wound Healing, Visual Disorders, 030104 developmental biology, medicine.anatomical_structure, MESH: Vision Disorders / physiopathology, Proteoglycans, Collagen, sense organs, Collagens, MESH: Proteoglycans / metabolism |
| الوصف: | International audience; The cornea represents the external part of the eye and consists of an epithelium, a stroma and an endothelium. Due to its curvature and transparency this structure makes up approximately 70% of the total refractive power of the eye. This function is partly made possible by the particular organization of the collagen extracellular matrix contained in the corneal stroma that allows a constant refractive power. The maintenance of such an organization involves other molecules such as type V collagen, FACITs (fibril-associated collagens with interrupted triple helices) and SLRPs (small leucine-rich proteoglycans). These components play crucial roles in the preservation of the correct organization and function of the cornea since their absence or modification leads to abnormalities such as corneal opacities. Thus, the aim of this review is to describe the different corneal collagens and proteoglycans by highlighting their importance in corneal transparency as well as their implication in corneal visual disorders. |
| تدمد: | 1432-0878 0302-766X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62260792949aba560b71ad7042d79632Test https://doi.org/10.1007/s00441-015-2233-5Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....62260792949aba560b71ad7042d79632 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320878 0302766X |
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